ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Arjun Singh

Email(s): arjunphar@gmail.com

DOI: 10.52711/0974-4150.2023.00077   

Address: Arjun Singh*
Department of Medicine, Sidney Kimmel Medical College,
Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author

Published In:   Volume - 16,      Issue - 6,     Year - 2023


ABSTRACT:
The global corona virus disease outbreak, also known as the COVID-19 pandemic outbreak, caused a major health crisis around the world. The morbidity and mode of transmission of COVID-19 appear to be more severe and uncontrollable. The main pathophysiology of this deadly disease is respiratory failure and subsequent cardiovascular complications. From a pharmacological standpoint, several therapeutic strategies have been proposed for the development of safe and effective treatment against the SARS-CoV-2 virus, but no specific treatment regimen has been developed for this viral infection to date. The current review focuses on the role of herbs and herbs-derived secondary metabolites in inhibiting the SARS-CoV-2 virus as well as in the management of post-COVID-19 complications. This strategy will promote and protect the use of medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been shown to prevent viral infection and to alleviate post-COVID complications such as parkinsonism, kidney and heart failure, liver and lung damage, and mental problems. We investigated mechanistic approaches of herbal medicines and their phytochemicals as antiviral and post-COVID complications by modulating immunological and inflammatory states in this review.


Cite this article:
Arjun Singh. A Review on the Ethnopharmacology, Phytochemistry and Pharmacology of Natural Phytochemicals used for Ameliorating/preventing SARS-CoV-2. Asian Journal of Research in Chemistry. 2023; 16(6):467-2. doi: 10.52711/0974-4150.2023.00077

Cite(Electronic):
Arjun Singh. A Review on the Ethnopharmacology, Phytochemistry and Pharmacology of Natural Phytochemicals used for Ameliorating/preventing SARS-CoV-2. Asian Journal of Research in Chemistry. 2023; 16(6):467-2. doi: 10.52711/0974-4150.2023.00077   Available on: https://ajrconline.org/AbstractView.aspx?PID=2023-16-6-13


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11.    Mishra, Disha, Jyotshna, Arjun Singh, D. Chanda, K. Shanker, and Puja Khare. Potential of Di-Aldehyde Cellulose for Sustained Release of Oxytetracycline: A Pharmacokinetic Study. International Journal of Biological Macromolecules. 2019; 136: 97–105. https://doi.org/10.1016/j.ijbiomac.2019.06.043.
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15.    Singh, Aastha, Kaneez Fatima, Ankita Srivastava, Sadiya Khwaja, Dev Priya, Arjun Singh, Girish Mahajan, et al. Anticancer Activity of Gallic Acid Template-Based Benzylidene Indanone Derivative as Microtubule Destabilizer. Chemical Biology and Drug Design. 2016; 88 (5): 625–34. https://doi.org/10.1111/cbdd.12805.
16.    Singh, Arjun, B. Sathish Kumar, Sarfaraz Alam, Hina Iqbal, Mohammad Shafiq, Feroz Khan, Arvind S. Negi, Kashif Hanif, and Debabrata Chanda. Diethyl-4,4ʹ-Dihydroxy-8,3ʹ-Neolign-7,7ʹ-Dien-9,9ʹ-Dionate Exhibits Antihypertensive Activity in Rats through Increase in Intracellular CGMP Level and Blockade of Calcium Channels. European Journal of Pharmacology. 2017; 799: 84–93. https://doi.org/10.1016/j.ejphar.2017.01.044.
17.    Singh, Arjun, B. Sathish Kumar, Hina Iqbal, Sarfaraz Alam, Pankaj Yadav, Amit Kumar Verma, Feroz Khan, et al. Antihypertensive Activity of Diethyl-4,4’-Dihydroxy-8,3’-Neolign-7,7’-Dien-9,9’-Dionate: A Continuation Study in L-NAME Treated Wistar Rats. European Journal of Pharmacology. 2019; 858: 172482. https://doi.org/10.1016/j.ejphar.2019.172482.
18.    Singh, Arjun, Ipsita Mohanty, Jagmohan Singh, and Satish Rattan. BDNF Augments Rat Internal Anal Sphincter Smooth Muscle Tone via RhoA/ROCK Signaling and Nonadrenergic Noncholinergic Relaxation via Increased NO Release. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2020; 318(1): 23–33. https://doi.org/10.1152/ajpgi.00247.2019.
19.    Singh, Arjun, and Satish Rattan. BDNF Rescues Aging-Associated Internal Anal Sphincter Dysfunction. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021; 321(1): G87–97. https://doi.org/10.1152/ajpgi.00090.2021.
20.    Singh, Arjun, Jagmohan Singh, and Satish Rattan. Evidence for the Presence and Release of BDNF in the Neuronal and Non‐neuronal Structures of the Internal Anal Sphincter. Neurogastroenterology and Motility. 2021. https://doi.org/10.1111/nmo.14099.
21.    Srivastava, Ankita, Kaneez Fatima, Eram Fatima, Arjun Singh, Aastha Singh, Aparna Shukla, Suaib Luqman, et al. Fluorinated Benzylidene Indanone Exhibits Antiproliferative Activity through Modulation of Microtubule Dynamics and Antiangiogenic Activity. European Journal of Pharmaceutical Sciences. 2020; 154: 105513. https://doi.org/10.1016/j.ejps.2020.105513.
22.    Yadav, Pankaj, Hina Iqbal, Kapil Kumar, Parmanand Kumar, Divya Mishra, Arjun Singh, Anirban Pal, et al. 2-Benzyllawsone Protects against Polymicrobial Sepsis and Vascular Hyporeactivity in Swiss Albino Mice. European Journal of Pharmacology. 2022; 917: 174757. https://doi.org/10.1016/j.ejphar.2022.174757.
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24.    Singh, Aastha, Fatima, K., Srivastava, A., Khwaja, S., Priya, D., Singh, Arjun, Mahajan, G., Alam, S., Saxena, A.K., Mondhe, D.M., Luqman, S., Chanda, D., Khan, F., Negi, A.S. Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer. Chem Biol Drug Des. 2016; 88: 625–634.
25.    Yadav, P., Iqbal, H., Kumar, K., Kumar, P., Mishra, D., Singh, A., Pal, A., Mukhopadhyay, P., Vamadevan, B., Singh, D., Negi, A.S., Chanda, D. 2-Benzyllawsone protects against polymicrobial sepsis and vascular hyporeactivity in swiss albino mice. European Journal of Pharmacology. 2022; 917: 174757.
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31.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-0. doi: 10.52711/2231-5713.2022.00055
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33.    Vishnu P K, Anil P V, Vyshak P K. Adaptation towards Green banking; exploring acceptance and awareness among stakeholders of Banking Industry; A Post COVID-19 outbreak analysis. Asian Journal of Management. 2022; 13(3):186-2.
34.    Rashmi Negi, Arti. Novel Coronavirus (COVID 19) Knowledge and Perception: A Survey of Healthcare workers. Asian Journal of Nursing Education and Research. 2021; 11(4):503-9.
35.    SamarpitaPramanik. Concerns regarding COVID-19 outbreak among healthcare workers. Asian Journal of Nursing Education and Research. 2022; 12(3):325-9.
36.    Ali Adel Dawood. Reasons for discontinuing the use of Hydroxychloroquine in the treatment of the Novel Coronavirus. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):179-0.
37.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-0. doi: 10.52711/2231-5713.2022.00055
38.    Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2):141-4.
39.    Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2): 162-6.
40.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2012; 4(4):349-0.
41.    Arjun Singh, Rupendra Kumar. An Overview on Ethnopharmacological, Phytochemical, and Clinical Significance of Selected Dietary Polyphenols. Asian Journal of Research in Chemistry. 2023; 16(1): 8-2.
42.    Arjun Singh. Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads. Asian Journal of Research in Chemistry. 2023; 16(1): 43-8.
43.    Singh, A., Chanda, D., Negi, A. S. (2018). Antihypertensive activity of Diethyl-4, 4'-dihydroxy-8, 3'-neolign-7, 7'-dien-9, 9'-dionate through increase in intracellular cGMP level and blockade of calcium channels (VDCC) and opening of potassium channel and in vivo models (SHRs and L-NAME induced hypertension). In Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) (pp. PO1-2). Japanese Pharmacological Society.


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