ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Mitesh D Phale, Purnima D Hamrapurkar

Email(s): phalemitesh@gmail.com

DOI: Not Available

Address: Mitesh D Phale*, and Purnima D Hamrapurkar
Department of Pharmaceutical Analysis, Prin. K. M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau
Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai- 400 005, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009


ABSTRACT:
A simple, specific, accurate, and precise reverse phase liquid chromatographic method (RP-HPLC) was developed and validated for the estimation of Metoprolol succinate from bulk drugs. A RP Spherisorb C-18 (Waters) 10µm column having 250×4.6 mm ID in isocratic mode, with mobile phase containing acetonitrile: methanol: 10 mM aqueous phosphate buffer (20:20:60%v/v) was used. The flow rate was 1.0 ml/min and effluents were monitored at 254 nm. The retention time of Metoprolol succinate was 5.1 min. The linearity of the method was good (r > 0.998), as also were intra-day and inter-day precision (RSD <2%). The method was validated for accuracy, specificity, limit of quantification, limit of detection, robustness and stability. The results showed that proposed method is successfully applied for the quantitative determination of Metoprolol succinate in bulk drugs.


Cite this article:
Mitesh D Phale, Purnima D Hamrapurkar. A Validated and Simplified RP-HPLC of Metoprolol Succinate from Bulk Drugs. Asian J. Research Chem. 2(2): April.-June, 2009 page 119-122.


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