ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): JR Rao, Mohan Kumar, SS Yadav

Email(s): janhavirao@rediffmail.com

DOI: Not Available

Address: JR Rao*, Mohan Kumar and SS Yadav
Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune – 411038, Maharashtra, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
A simple, sensitive, selective, precise and reversed-phase stability-indicating HPLC method was developed and validated for Bumetanide (BUM) in bulk drug and in formulation. The method has shown adequate separation for BUM from their associated impurities and their degradation products. Separation was achieved on a Waters Spherisorb ODS2 C18, 250 mm × 4.6 mm i.d., 5 µm column using a mobile phase consisting of methanol: water (70:30, v/v) at a flow rate of 1ml/min and UV detection at 335 nm and the retention time (TR) was found to be 4.743 ± 0.05 min. The method was also applied for the determination of BUM in the presence of their degradation products formed under variety of stress conditions. Proposed method was validated for precision, accuracy, linearity range, recovery and robustness.


Cite this article:
JR Rao, Mohan Kumar, SS Yadav. Stability Indicating RP- HPLC Method for Bumetanide in Bulk Drug and Tablet Formulation. Asian J. Research Chem. 2(3): July-Sept. 2009 page 266-269.


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