ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): T Venkatachalam, S Narendiran, P Kalai Selvi, P Dheen Kumar

Email(s): venkatachalammpharm@yahoo.co.in

DOI: Not Available

Address: T Venkatachalam*1, S Narendiran1, P Kalai Selvi1 and P Dheen Kumar2
1Dept. of Pharmaceutical Chemistry, JKKMMRF College of Pharmacy, Komara Palayam -638183.Tamil Nadu, India
2 Dept. of Pharmaceutical Chemistry, Maharaji College of Pharmacy, Chennai 600090.Tamil Nadu, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
A simple, precise, accurate and rapid HPLC method has been developed, and validated for the determination of ofloxacin and satranidazole simultaneously ,in combined dosage form. Acetonitrile and ammonium di-hydrogen orthophosphate buffer with ph7.0 (50%:50%)is used as the mobile phase ,300 is the detection wavelength for this study. The applicability of the method for simultaneous determinations of oflaxacin and satranidazole was verified by the determination of these compounds in marketed tablets .Results of the analysis were validated statistically, and by recovery studies (99.43-101.28 %). The recovery and RSD values with in limits given in ICH guidelines method developments indicates that the suitability of proposed for the routine determination of the these compounds in tablets .the validation parameters; linearity (r=9999) sensitivity (LOD (1.0 -1.5x10-4), LOQ(3.0-4.5×10-4) accuracy(99.43 -101.28 %) and reproducibility were found to satisfactory. The proposed method can be successfully used to determine the drug contents of marketed formulation.


Cite this article:
T Venkatachalam, S Narendiran, P Kalai Selvi, P Dheen Kumar. RP-HPLC Method for Simultaneous Determination of Ofloxacin and Satranidazole in Tablet Dosage Form. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 469-471.


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