ABSTRACT:
Phosphoramidates (N-P) are biologically active organic compounds because they are capable of inhibiting enzyme action. A few members of this class were synthesized and checked for their anticholinesterase properties and they were found to be a good reactive phosphorylating agent to block AChE rather than BuChE in the poisoning process. The presence of chloro-substituent (either ortho- or para-) in the aryl moiety of these phosphoramidates does not show any significant contribution during toxicological study made in vitro. These phosphoramidates were characterized by FT-IR, 31P NMR and GC-MS spectral studies.
Cite this article:
Soram Ibomcha Singh, Shashi Prabha. Synthesis, Identification of Some P-Chiral Organic Phosphoramidates and Their Inhibitory Action towards Enzymes. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 523-525.
Cite(Electronic):
Soram Ibomcha Singh, Shashi Prabha. Synthesis, Identification of Some P-Chiral Organic Phosphoramidates and Their Inhibitory Action towards Enzymes. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 523-525. Available on: https://ajrconline.org/AbstractView.aspx?PID=2009-2-4-41