ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Prabhu C Jalihal, Suresh Sharabsappa, Basavaraj Kilarimath

Email(s): prabhu_mpharm@rediffmail.com

DOI: Not Available

Address: Prabhu C Jalihal1*, Suresh Sharabsappa2 and Basavaraj Kilarimath2
1Department of Pharmaceutical Chemistry H.S.K. College of Pharmacy Bagalkot 580071 Karnataka
2Department of Pharmaceutical Chemistry KLE’S College of Pharmacy, Vidyanagar, Hubli 580031, Karnataka
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
Ortho, meta and para-nitroaniline was treated with methyl methacrylate in the presence of acetic acid to get methyl 2-methyl-3-(o, m and p-nitroanilino)propionates which was further treated with hydrazine hydrate (99 %) in the presence of absolute ethanol to get 2-methyl-3-(o, m and p-nitroanilino) propanohydrazide. The above compound was then treated with carbon disulphide in the presence of alcoholic KOH and ethanol as a solvent to get 5-{1-methyl-2-(o, m andp-nitroanilino) ethyl}-1,3,4-oxadiazole-2-thiol.These compounds were further treated with mopholine / piperidine / diethyl amine/ dimethyl amine / diphenyl amine to get title compounds. The newly synthesized compounds were characterized by spectral and elemental analysis and the compounds were tested for antimicrobial activity.


Cite this article:
Prabhu C Jalihal, Suresh Sharabsappa, Basavaraj Kilarimath. Synthesis and Antimicrobial Activity of Some New 2, 5-Disubstituted 1, 3, 4-Oxadiazoles. Asian J. Research Chem. 3(2): April- June 2010; Page 319-323.


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RNI: Not Available                     
DOI: 10.5958/0974-4150 

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