Novel N-phenyl-a-amino nitrone has been synthesized from formamide and one pot facile 1,3-Dipolar cycloaddition reactions of the nitrone have been studied in water at room temperature in the stereoselective synthesis of novel isoxazolidine derivatives. Significant rate acceleration, changes in stereoselectivity and high yield of these reactions are observed in water compared to organic solvents.
Cite this article:
Bhaskar Chakraborty, Neelam Rai. Green Synthesis of Isoxazolidines: One Pot Facile Cycloaddition Reactions of Novel N-Phenyl-α-Amino Nitrone in Water. Asian J. Research Chem. 4(2): February 2011; Page 289-292.