ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sudhir Bharadwaj, Bharat Parashar, Dimple K. Rathore, V.K. Sharma

Email(s): dimplerathore83@gmail.com

DOI: Not Available

Address: Sudhir Bharadwaj1, Bharat Parashar2, Dimple K. Rathore3* and V.K. Sharma3
1 Shriram College of Pharmacy, Bamor, Murana (M.P.)
2Geetanjali Institute of Pharmacy, Dabok,, Udaipur (Rajasthan)
3Microwave Chemistry Laboratory
M.L.Sukhadia University, Udaipur (Rajasthan *Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2011


ABSTRACT:
1-isonicotinoylpyrazolidine-3, 5-dione (1) has been synthesized by the condensation of isonicotinohydrazide, diethyl malonate and a catalytic amount of glacial acetic acid. A number of 1- isonicotinoylpyrazolidine-3, 5-dione derivatives have been synthesized by the reaction of (1) with various primary as well as secondary amines in the presence of formaldehyde. The reactions have been carried out following conventional procedure and also under microwave irradiation. The microwave-assisted reactions are rapid, safe, high yielding and superior to conventional methods. The structures of all the products are characterized by micro analytical data and spectroscopic techniques. All the synthesized products are screened for their antibacterial activity against E. coli, P. aeriginosa, B. subtillis S. aureus and C. albicans, A. niger.


Cite this article:
Sudhir Bharadwaj, Bharat Parashar, Dimple K. Rathore, V.K. Sharma. Synthesis and Antimicrobial Activity of Mannich Bases of 1-Isonicotinoylpyrazolidine-3, 5-Dione. Asian J. Research Chem. 4(3): March 2011; Page 455-460.


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