ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Subal Debnath, S.Y. Manjunath

Email(s): subal_2007@yahoo.co.in

DOI: Not Available

Address: Subal Debnath* and S.Y. Manjunath
Department of Pharmaceutical Chemistry, Srikrupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Mdl: Kondapak, Dist. Medak, Siddipet, Andhra Pradesh – 502 277, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 9,     Year - 2011


ABSTRACT:
The present research work were aimed to synthesize a series of various substituted quinazolinone containing 3-(Substituted)-2-phenylquinazolin-4(3H)-one. The compound 2-Phenyl-4H-3,1-benzoxazin-4-one, I were prepared by treating anthranilic acid with benzoyl chloride in pyridine. Synthesis of 3-Amino-2-phenylquinazolin-4(3H)-one, II carried out by reacting, I with hydrazine hydrate in ethanol. The compound 2-{[(4-Oxo-2-phenylquinazolin-3(4H)-yl)-amino]carbonyl}benzoic acid, III obtained by reacting II with phthalic anhydride in ethanol. Synthesis of 2-Phenyl-3- [{-(4-substituted)-phenylmethylene}-amino]-quinazolin-4(3H)-one, IV(a-b) were done by reacting II with 4-Substituted benzaldehyde in glacial acetic acid. Synthesis of N-(4-Oxo-2-phenylquinazolin-3(4H)-yl)benzamide, V were done by reacting II with benzoyl chloride in pyridine. Finally, 3-[3-(2,4-Dichlorophenoxy)-3-(4-substituted phenyl)-2-oxoazetidin-1-yl]-2-phenylquinazolin-4(3H)-one, VI(a-b) were synthesized by reacting IV(a-b) with 2,4-Dichlorophenoxyacetic acid and thionyl chloride in benzene. These derivatives were prepared by microwave as well as conventional method. Structure of the compounds has been established by means of IR, 1H-NMR and MS. All the compounds were evaluated for antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Most of the compounds showed significant antibacterial activities when compared with the standard drug ciprofloxacin at the concentration of 500 µg/ml and 250 µg/ml. In this research work, in vitro anthelmintic activity of 3-(Substituted)-2-phenylquinazolin-4(3H)-one carried out in comparison with piperazine citrate. These newly synthesized quinazolinone derivatives showed paralysis and followed by death at concentration of 10 mg/ml for the screening of anthelmintic activity. These derivatives also screened for analgesic and anti-inflammatory activity. The results showed that synthesized compound having moderate analgesic and anti-inflammatory activity.


Cite this article:
Subal Debnath, S.Y. Manjunath. Antibacterial, Anthelmintic, Analgesic and Anti-Inflammatory Activity of Conventional and Microwave Assisted Synthesized 3-(Substituted)-2-Phenylquinazolin-4(3h)-One. Asian J. Research Chem. 4(9): Sept, 2011; Page 1453-1459.


Recomonded Articles:

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Author(s): Maqdoom Farooqui, Syed Nazimuddin

DOI: 10.5958/0974-4150.2017.00026.8         Access: Open Access Read More

Author(s): Gangadhara MM, Dinesha R, Satish Kumar Murari

DOI: 10.5958/0974-4150.2017.00020.7         Access: Open Access Read More

Author(s): Trapti Rastogi, Vijay Bhutda, Komal Moon, PB Aswar, SS Khadabadi

DOI:         Access: Open Access Read More

Author(s): KP Bhusari, ND Amnerkar, PB Khedekar, MK Kale, RP Bhole

DOI:         Access: Open Access Read More

Author(s): SR Pattan, NS Dighe, SA Nirmal, AN Merekar, RB Laware, HV Shinde, DS Musmade

DOI:         Access: Open Access Read More

Author(s): S.B. Junne, Archana B. Kadam, Archana Y. Vibhute, S.L. Shinde, R.B. Patil, Y.B. Vibhute

DOI:         Access: Open Access Read More

Author(s): Sapna Tyagi, Tanveer Alam, Mohd Azhar Khan, Hina Tarannum, Neha Chauhan

DOI: 10.5958/0974-4150.2018.00092.5         Access: Open Access Read More

Author(s): Anshul Sinha, A. K. Meena, P. Panda, Bhavana Srivastava, M. D. Gupta, M. M. Padhi

DOI:         Access: Open Access Read More

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Author(s): S. N. Battin, A. H. Manikshete, S. K. Sarasamkar, M. R. Asabe, D. J. Sathe

DOI: 10.5958/0974-4150.2017.00112.2         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags