Asian Journal of Research in Chemistry

ISSN

0974-4150 (Online)
0974-4169 (Print)


Submit Article

Microwave Mediated Synthesis, Characterisation and Biological activity of Certain New Mannich Bases of Isatin and Coumarin

Author(s): N. Habeela Jainab, P. Sivachidambaram, J. Yuvaraju, K. Jesintha Beyatricks, Bincy Raj

Email(s): habi.asheesh@gmail.com

DOI: Not Available

Address: N. Habeela Jainab, P. Sivachidambaram, J. Yuvaraju, K. Jesintha Beyatricks, Bincy Raj
Hillside College of Pharmacy and Research Centre, Bangalore-62.
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2014

 View HTML        View PDF

ABSTRACT:
In the present study Schiff’s bases of isatin were synthesized by condensation of the keto group of isatin with the 4-methyl coumarinyl-7-oxyacetic hydrazide. The N-mannich bases of the above Schiff’s bases were synthesized by reaction of acidic imino group of isatin with formaldehyde and various primary or secondary amines. In this current study, microwave assisted parallel synthesis along with the conventional method was opted for synthesizing Schiff’s and Mannich bases of isatin and their efficacies based on the percentage yield and consumption of time for synthesis by each method were compared. The compounds synthesized were screened against some selected gram (+)ve and gram (-)ve microorganisms and activities were compared with a standard antibiotic. Similarly the prepared compounds were also subjected for antifungal screening, where activities were compared with standard antifungal agent. The compounds synthesized were also evaluated for antioxidant activity and compared with standard drug (ascorbic acid). Antioxidant activity was done by DPPH method.


Keywords:

Cite this article:
N. Habeela Jainab, P. Sivachidambaram, J. Yuvaraju, K. Jesintha Beyatricks, Bincy Raj. Microwave Mediated Synthesis, Characterisation and Biological activity of Certain New Mannich Bases of Isatin and Coumarin. Asian J. Research Chem. 7(2): February 2014; Page 176-181.

Cite(Electronic):
N. Habeela Jainab, P. Sivachidambaram, J. Yuvaraju, K. Jesintha Beyatricks, Bincy Raj. Microwave Mediated Synthesis, Characterisation and Biological activity of Certain New Mannich Bases of Isatin and Coumarin. Asian J. Research Chem. 7(2): February 2014; Page 176-181.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2014-7-2-13


Recomonded Articles:

A Review of Imidazole Derivatives: Synthesis, Pharmacological Applications, and Future Perspectives

Author(s): Rakesh Kumar

DOI: 10.52711/0974-4150.2024.00062         Access: Open Access Read More

Synthesis and Biological Screening of Novel Aminoalkyl Substituted Azaphenothiazine

Author(s): P. Valentina, K. Ilango, Deepak Jain, Prerna Shukla

DOI:         Access: Open Access Read More

Structural and Biological Activity Studies on Metal Complexes Containing Thiosemicarbzone and Isatin Based Schiff Base: A Review

Author(s): Saddam Hossain, C. M. Zakaria, Kudrat-E-Zahan

DOI: 10.5958/0974-4150.2017.00002.5         Access: Open Access Read More

Synthesis, Characterisation, DNA binding/cleavage, anticancer and antimicrobial activity of Ternary Copper(II) Complexes

Author(s): S. Dhakshanamoorthy, M. Murali Krishnan, M.N. Arumugham

DOI: 10.5958/0974-4150.2017.00052.9         Access: Open Access Read More

1,3,4- Oxadiazole, A Complete Review on Biological Activities of Newly Synthesized Derivatives

Author(s): Amisha Bhopatrao, Pooja Chavan, Hritisha Chavan, Pravin Chaudhari, Zahra Dadan, Ajay Kharche

DOI: 10.52711/0974-4150.2024.00043         Access: Open Access Read More

Schiff base metal complexes: Synthesis, Characterization, Thermal Analysis and Antibacterial Activity

Author(s): Tuly Paul, Faruk Hossen, Kudrat-E-Zahan, Masuqul Haque, Saddam Hossain, Rausan Zamir, Ali Asraf

DOI: 10.5958/0974-4150.2020.00052.8         Access: Open Access Read More

A Current Study on Benzimidazole Derivatives

Author(s): Y. Dattatri , R. Harika, Chaitanya Prasad Meher, P. Divyajyothi, R. Sangeetha, P. Santosh

DOI:         Access: Open Access Read More

Synthesis of Some Chalcone and Their Heterocyclic Derivatives as Potential Antimicrobial Agents: A Review.

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Phytochemical, Pharmacological and Therapeutic Potential of Hordeum vulgare Linn. - A Review

Author(s): Anshul Sinha, A. K. Meena, P. Panda, Bhavana Srivastava, M. D. Gupta, M. M. Padhi

DOI:         Access: Open Access Read More

Synthesis and SAR Study of Some New Benzhydryl Piperazine Sulfonamide and Carboxamide as Antimicrobial Agents

Author(s): Patel R.C , Patel C.N, Panigrahi B.B., Bhaskar V.H.

DOI:         Access: Open Access Read More

Synthesis and antimicrobial evaluation of Azetidinone derivatives of pyridine containing hydrazides

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Studies on the Pollution Potential of Vaigai River at Madurai, India

Author(s): C.Balamurugan, L. Leena Hebsibai

DOI:         Access: Open Access Read More

Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Biodiversity of Oxazolone Derivatives in Medicinal Chemistry: A Review

Author(s): Suman Bala, Minaxi Saini, Sunil Kamboj, Goldie Uppal, Ashok Kumar

DOI:         Access: Open Access Read More

A Review on Pyranocoumarins and its biological importance

Author(s): K.P. Beena, G. Sathya Pooja

DOI: 10.52711/0974-4150.2022.00030         Access: Open Access Read More

Synthesis and In Vitro Antimicrobial Activity of Some New 4-Amino-N-(1,3- Benzothiazol-2-yl) benzenesulphonamide Derivatives

Author(s): KP Bhusari, ND Amnerkar, PB Khedekar, MK Kale, RP Bhole

DOI:         Access: Open Access Read More

Antibacterial Screening of Clerodendrum infortunatum leaves: Experimental and Molecular docking studies

Author(s): Sindhu. T. J, Akhilesh K. J, Anju. Jose, Binsiya K. P, Blessy Thomas, Elizabeth Wilson

DOI: 10.5958/0974-4150.2020.00026.7         Access: Open Access Read More

A Review Report on Active Methylene group in Malononitrile

Author(s): Suman Kumari, Vinita Gupta, Sanchita Singh3, Y.K. Gupta

DOI: 10.5958/0974-4150.2018.00153.0         Access: Open Access Read More

The Evaluation of Nitric Oxide Scavenging Activity of Acalypha Indica Linn Root

Author(s): Balakrishnan N, Panda A B, Raj N R, Shrivastava A, Prathani R

DOI:         Access: Open Access Read More

Pharmacognostic and Preliminary Phytochemical Screening of Cichorium intybus Linn Seed

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Quick Links

Latest Issues

Popular Articles


Recent Articles



Rapid Synthesis of Indazole derivatives using Microwave Technology, its Characterisation and Anti-Inflammatory effects Observed in Laboratory Tests
Simple Extractive Spectrophotometric Method for Determination of Drotaverine Hydrochloride by Reactive Dyes from Pharmaceutical Dosage Form
Integrative Role of Jawārish Falāfilī: Unani Principles and Biomedical Evidence in Managing Metabolic and Gastrointestinal Disorders
Application of Mxenes in Environmental Pollution Control and Water Remediation- A Far-Reaching and An Insightful Review
Modern Approaches to the Synthesis of Triazole Derivatives: Advances in Catalysis and Green Chemistry
The Journey of Extraction: Review from Ancient Practices to Modern Technologies
Estimation of Drotaverine hydrochloride by extractive colorimetric Methods in Bulk and Pharmaceutical Dosage Form
Novel-Biosynthesis and Characterization of Anethum graveolens gold Nanoparticles: In-vitro activity against Hepatocellular Carcinoma with Molecular Docking Approach
Cancer: A Multifaceted Disease and Therapeutic Potential of Benzimidazole as Anticancer Agents
In Silico Drug-Likeness, ADMET, Toxicity Profiling of Clinically Relevant Antidiabetic agents
Determination of Candesartan cilexetil from pharmaceutical dosage form by extractive ion pair complex colorimetric method
Anti-Microbial Evaluation of Newly Synthesized Hetero-Aryl Thiazole Derivatives
Recent Advances in Pharmaceutical Quality Risk Management Strategies and Tools
The Role and Significance of Rasa-Aushadhis in Ayurvedic Pharmacology: A Comprehensive Overview
QSAR Study of 1, 2, 4-Triazole for their Anticancer Activity
Review on Natural Remedies for COPD: Development of Synergistic Herbal Syrup
Advancing Protein Therapeutics: Innovations In Rational Drug Design: A Review
Chromenes As Antimicrobial Agents: Mechanisms, Efficacy, And Future Perspectives
A Systematic Review - Adverse Effect of Covid-19 Vaccine
Exploring Binding Affinities and Interactions of Benzimidazole Derivatives via AutoDock Molecular Docking Studies

Tags


About Journal

Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
Read More  

Visitors

Today: 1770
Yesterday: 3226
Total: 2389070