ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): K. Hemalatha, V. Chakkaravarthi, K. Ganesa Murthy, R. Kayatri, K. Girija

Email(s): hemalathampharm@gmail.com

DOI: Not Available

Address: K. Hemalatha*, V. Chakkaravarthi, K. Ganesa Murthy, R. Kayatri, K. Girija
Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Government of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-06., India
*Corresponding Author

Published In:   Volume - 7,      Issue - 7,     Year - 2014


ABSTRACT:
Peptide deformylase (PDF), a metallohydrolase essential for bacterial growth, which is an attractive target for use in the discovery of novel antibiotics. The present study involves the molecular docking analysis of Schiff’s and Mannich bases of benzimidazole derivatives as inhibitors of Escherichia coli PDF. A series of benzimidazole derivatives were designed and optimized with Auto Dock 4.0.1 to investigate the interaction between the target ligand and the amino acid residues of Escherichia coli PDF. The free energies of binding (?G) and inhibition constants (Ki) of the docked ligands were calculated by Lamarckian Genetic Algorithim. The molecular properties were analysed by using Mol inspiration software. Comparative study of molecular properties and the binding score obtained by docking of known inhibitor (Actinonin) and the designed compounds suggest that some of these derivatives can be used as potential inhibitors of Escherichia coli PDF.


Cite this article:
K. Hemalatha, V. Chakkaravarthi, K. Ganesa Murthy, R. Kayatri, K. Girija. Molecular Properties and Docking Studies of Benzimidazole Derivatives as Potential Peptide Deformylase Inhibitors. Asian J. Research Chem. 7(7): July 2014; Page 644-648.


Recomonded Articles:

Author(s): Vijaya B Reddy, Rajeev K, Singla Varadaraj Bhat G, Gautham G Shenoy

DOI:         Access: Open Access Read More

Author(s): G. Venkateswararao, G.SatyaSree, B. SathishMohan, K. Ravi

DOI: 10.5958/0974-4150.2018.00093.7         Access: Open Access Read More

Author(s): Kumaraswamy Gullapelli, M. Ravichander, P. Bhaskar, K. Jagadeesh Babu, G. Brahmeshwari

DOI: 10.5958/0974-4150.2017.00083.9         Access: Open Access Read More

Author(s): Jacob Jincy, Dey Tathagata, Ghate Manjunath, Baby Shaji

DOI:         Access: Open Access Read More

Author(s): Rohit Tripathi, Arvind Kumar Singh, Vipul Singh, Preety Mishra, Roopesh Maurya

DOI:         Access: Open Access Read More

Author(s): YS Rane, RR Varma, LS Patil, SV Athlekar, AS Chowdhary, AS Bobade

DOI:         Access: Open Access Read More

Author(s): Prashant N. Ubale, Sambhaji P. Vartale, Sandip G. Sontakke

DOI: 10.5958/0974-4150.2017.00095.5         Access: Open Access Read More

Author(s): Y. Dattatri , R. Harika, Chaitanya Prasad Meher, P. Divyajyothi, R. Sangeetha, P. Santosh

DOI:         Access: Open Access Read More

Author(s): Arun B. Chavan, Momin K.I., Bondge A.S., Jairaj K. Dawle

DOI: 10.5958/0974-4150.2016.00074         Access: Open Access Read More

Author(s): K. Durga Prasad, M. Sandhya Rani, D. Anusha

DOI: 10.5958/0974-4150.2018.00045.7         Access: Open Access Read More

Author(s): K. Hemalatha, V. Chakkaravarthi, K. Ganesa Murthy, R. Kayatri, K. Girija

DOI:         Access: Open Access Read More

Author(s): Mohan Rao Gangula, Vijaya Kumar Baru

DOI:         Access: Open Access Read More

Author(s): Pratik P. Maske, Sunil Nalavade, Shobhraj B. Malavi, Somkant V. Jawarkar, Rameshwar M. Ardad, Sachin G. Lokapure

DOI: 10.5958/0974-4150.2015.00029.2         Access: Open Access Read More

Author(s): Praneetha V, Sreerama Usha Rani, K Srinivas

DOI: 10.5958/0974-4150.2016.00069.9         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags