ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Ganesh Akula, Bollaboina Venkatesh, K. Sanjayraj, S.S. Phanindra, A. Jaswanth

Email(s): akulaganesh@gmail.com

DOI: 10.5958/0974-4150.2016.00011.0   

Address: Ganesh Akula1*, Bollaboina Venkatesh2, K. Sanjayraj2, S.S. Phanindra2, Dr. A. Jaswanth3
1Department of Pharmaceutical Chemistry, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Gajwel, Medak (dt)-502312, Telangana, India.
2Department of Pharmaceutical Analysis, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Gajwel. Medak (Dt)-502312, Telangana, India.
3Department of Pharmacology, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Gajwel, Medak (Dt)-502312, Telangana, India.
*Corresponding Author

Published In:   Volume - 8,      Issue - 2,     Year - 2015


ABSTRACT:
A simple, accurate, precise, rapid and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of Simvastatin and Niacin in Pure and Tablet dosage forms. Inertsil ODS, RP-18 Column (250 x 4.6 mm ID, 5µ) was used with a mobile phase containing a mixture of Phosphate buffer pH 2.5, Methanol and Acetonitrile in the ratio of 45:20:35. The procedure was carried out at pH-3.5. The compounds were eluted at a flow rate of 1.0 ml/min. results were determined at 220 nm with fixed wavelength PDA detector. The linearity for Niacin was found between 75-175 µg/ml and between 3-7 µg/ml for Simvastatin. The retention times were found as 4.747 min and 2.970min for Niacin and Simvastatin respectively. The above method was validated in terms of System suitability, linearity, accuracy, precision, Limit of Detection (LOD), Limit of Quantification (LOQ), Robustness in accordance with ICH guidelines. The method was rapid, simple, economical and suitable for routine quality control analysis.


Cite this article:
Ganesh Akula, Bollaboina Venkatesh, K. Sanjayraj, S.S. Phanindra, A. Jaswanth. Validated RP-HPLC Method for the Simultaneous Estimation of Simvastatin and Niacin. Asian J. Research Chem. 9(2): Feb., 2016; Page 62-66. doi: 10.5958/0974-4150.2016.00011.0

Cite(Electronic):
Ganesh Akula, Bollaboina Venkatesh, K. Sanjayraj, S.S. Phanindra, A. Jaswanth. Validated RP-HPLC Method for the Simultaneous Estimation of Simvastatin and Niacin. Asian J. Research Chem. 9(2): Feb., 2016; Page 62-66. doi: 10.5958/0974-4150.2016.00011.0   Available on: https://ajrconline.org/AbstractView.aspx?PID=2015-8-2-14


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