ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Dimple K. Rathore, Vinod K. Sharma

Email(s): dimple01rathore@gmail.com

DOI: 10.5958/0974-4150.2016.00070.5   

Address: Dr. Dimple K. Rathore*, Dr. Vinod K. Sharma
Microwave Chemistry Laboratory, M. L. Sukhadia University, Udaipur, Rajasthan, India.
*Corresponding Author

Published In:   Volume - 9,      Issue - 10,     Year - 2016


ABSTRACT:
A series of imidazole derivatives were synthesized by condensation of, differently substituted 4-benzylidene-2-phenyloxazol-5(4H)-one and ammonia, which on further reaction with barbituric acid produces the final products (substituted 5-((5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-4-yl)methyl)pyrimidine-2,4,6(1H,3H,5H)-triones) 3(a-f). The structures of the newly synthesized compounds were supported by IR, 1H NMR, 13C NMR and MASS spectral data. All the reactions were carried out by environmental benign, efficient and extremely fast procedure microwave assisted synthesis. The derivatives of these moieties were screened for antibacterial and antifungal activity. It was seen that the compounds showed more antibacterial activity towards the test organisms S. pyogenus and S. aureus and significant activity against all strains of fungi.


Cite this article:
Dimple K. Rathore, Vinod K. Sharma. A Convenient, Rapid Microwave Assisted Synthesis of Some Novel Imidazole Derivatives and Their Antimicrobial Activity. Asian J. Research Chem. 2016; 9(10):469-474. doi: 10.5958/0974-4150.2016.00070.5

Cite(Electronic):
Dimple K. Rathore, Vinod K. Sharma. A Convenient, Rapid Microwave Assisted Synthesis of Some Novel Imidazole Derivatives and Their Antimicrobial Activity. Asian J. Research Chem. 2016; 9(10):469-474. doi: 10.5958/0974-4150.2016.00070.5   Available on: https://ajrconline.org/AbstractView.aspx?PID=2016-9-10-3


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