ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rabinarayana Sahu, Pramoda Kumar Das, Bamakanta Garnaik

Email(s): bama_61@rediffmail.com

DOI: 10.5958/0974-4150.2017.00128.6   

Address: Rabinarayana Sahu1, Pramoda Kumar Das2, Bamakanta Garnaik1*
1P. G. Department of Chemistry, Berhampur University, Bhanja Bihar- 760007 Odisha, India
2Kendrapara Autonomous College, Kendrapara, Odisha
*Corresponding Author

Published In:   Volume - 10,      Issue - 6,     Year - 2017


ABSTRACT:
Extensive biochemical and pharmacological studies of indole derivatives have confirmed their highly effectiveness against various strains of micro organisms as well as have various therapeutic effects. Inspired by these observations, in this research work, some substituted indoles i.e. 2(([1,3,4] Thiadiazino [6,5- b] indol-3-ylimino) methyl)substituted phenols are synthesized and their inclusion complexes have been prepared with ß -Cyclodextrin to enhance their stability, solubility, bio-accessibility and hence pharmacological activities. The formation of both synthesized pharmacophores and their inclusion complexes are established on the basis of elemental, thermal and spectral (UV, FT-IR, 1HNMR etc.)studies. The comparative biological screening of the synthesized compounds and their inclusion complexes are made for different bacterial strains, fungi and antioxidant character. The results of the research authenticate the fact that the inclusion complexes of the synthesized compounds exhibit profound antibacterial, antifungal and radical scavenging property with respect to their bared compounds.


Cite this article:
Rabinarayana Sahu, Pramoda Kumar Das, Bamakanta Garnaik. Synthesis, Characterization and Evaluation of Pharmacological Potential of inclusion Complexes of 2(([1,3,4] Thiadiazino [6,5-b] indol-3-ylimino) methyl) Phenol and its Derivatives with β -Cyclodextrin. Asian J. Research Chem. 2017; 10(6):757-764. doi: 10.5958/0974-4150.2017.00128.6


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