ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sushil D. Patil, Shaikh Abdul Muqeet, Sanjay J. Kshirsagar

Email(s): sushilpharma@rediffmail.com

DOI: 10.5958/0974-4150.2019.00003.8   

Address: Sushil D. Patil*, Shaikh Abdul Muqeet*, Dr. Sanjay J. Kshirsagar
MET’s Institute of Pharmacy, MET League of Colleges, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra State 422003, India
*Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2019


ABSTRACT:
A simple, rapid, accurate and precise RP-HPLC method has been developed and validated for the determination of Canagliflozin using Grace C18 (250mm x 4.6 I.D, Particle size:5 micron) with mobile phase consisting of Methanol: Water (90:10% v/v). The flowrate was 0.9mL/min. The detection was carried out at wavelength 290nm.The retention time of canagliflozin were found to be at 4.413min. In calibration curve experiments, Linearity was found to be in concentration range 1-5 µg/mL(R2= 0.998) with regression equation y=33918x+85331. Canagliflozin was subjected to stress condition including acidic, alkaline, oxidation and photolytic. The method was validated for linearity, precision, accuracy and robustness. The proposed method was successfully used for estimation of Canagliflozin in bulk and tablet dosage form. Validation studies revealed that method is rapid, reliable and reproducible.


Cite this article:
Sushil D. Patil, Shaikh Abdul Muqeet, Sanjay J. Kshirsagar. Development and Validation of Stability Indicating RP-HPLC Method for Canagliflozin. Asian J. Research Chem. 2019; 12(1): 11-15. doi: 10.5958/0974-4150.2019.00003.8

Cite(Electronic):
Sushil D. Patil, Shaikh Abdul Muqeet, Sanjay J. Kshirsagar. Development and Validation of Stability Indicating RP-HPLC Method for Canagliflozin. Asian J. Research Chem. 2019; 12(1): 11-15. doi: 10.5958/0974-4150.2019.00003.8   Available on: https://ajrconline.org/AbstractView.aspx?PID=2019-12-1-3


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DOI: 10.5958/0974-4150 

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