ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): P Nagaraju, K Krishnachaithanya, VDN Srinivas, SVN Padma

Email(s): raju_pharma35@rediffmail.com

DOI: Not Available

Address: P Nagaraju, K Krishnachaithanya, VDN Srinivas, SVN Padma
Department of Pharmaceutical analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur. India.
*Corresponding Author

Published In:   Volume - 1,      Issue - 2,     Year - 2008


ABSTRACT:
A simple, sensitive, precise and specific reverse phase high performance liquid chromatographic method was developed and validated for the determination of Ethamsylate in bulk and its tablet dosage forms. It was found that the excipient in the tablet dosage forms does not interfere in the quantification of active drug by proposed method. The HPLC separation was carried out by reverse phase chromatography on C18 column (4.6 x 250 mm, 5µm particle size) with a mobile phase composed of methanol: acetonitrile: acetate buffer PH 2.8 (60:30:10 v/v) in isocratic mode at a flow rate of 1 ml / min. The detection was monitored at 290 nm. The calibration curve for Ethamsylate was linear from 0.5 – 100 µg/ml. The interday and intraday precision (relative standard deviation) was found to be within the limits. The proposed method has adequate sensitivity, reproducibility and specificity for the determination of Ethamsylate in bulk and its tablet dosage forms.


Cite this article:
P Nagaraju, K Krishnachaithanya, VDN Srinivas, SVN Padma. Reverse Phase High Performance Liquid Chromatographic Method for the Determination of Ethamsylate in Bulk and Tablet Dosage Forms. Asian J. Research Chem. 1(2): Oct.-Dec. 2008; Page 88-90.


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