Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Spectrophotometric Method for Simultaneous Estimation of Paracetamol and Domperidone in Tablet Formulation

Author(s): Kalra Kapil, Naik S, Jarmal Garima, Mishra N

Email(s): kapil752003@yahoo.com

DOI: Not Available

Address: Kalra Kapil*, Naik S, Jarmal Garima and Mishra N
Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela, Orissa
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009

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ABSTRACT:
The development of Vireodt's method for simultaneous estimation of paracetamol and domperidone involves absorbance measurement at 250 nm and 285 nm corresponding to the respective absorption maxima. Both the drugs obey Beer Lambert's law in the range of 5-30 µg/ml for paracetamol and 0.8-5 µg/ml for domperidone. The tablet formulation (Grenil, KAPL) was evaluated for the percent content of both the drugs at the selected wavelengths. The method developed was validated to determine its accuracy, precision, specificity and ruggedness. The recovery study was carried out by standard addition method. The average percent recovery was found to be 99.45±0.47 for paracetamol and 100.67±0.18 for domperidone.


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Cite this article:
Kalra Kapil, Naik S, Jarmal Garima, Mishra N. Spectrophotometric Method for Simultaneous Estimation of Paracetamol and Domperidone in Tablet Formulation. Asian J. Research Chem. 2(2): April.-June, 2009 page 112-114.


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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DOI: 10.5958/0974-4150 

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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