ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Bhavna Patel, Zarna Dedania, Ronak Dedania, Chetan Ramolia, G Vidya Sagar, Mehta RS

Email(s): zaroo229@yahoo.co.in

DOI: Not Available

Address: Bhavna Patel1, Zarna Dedania, Ronak Dedania, Chetan Ramolia2, G Vidya Sagar and Mehta RS3
Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Kutch, Gujarat, India
1Ramanbhai Patel College of Pharmacy, Changa, Gujarat, India
2CRO, Veeda, Ahmedabad, Gujarat, India
3A.R. College of Pharmacy, Vallabh Vidhyanagar, Gujarat, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009


ABSTRACT:
A RP-HPLC method has developed for simultaneous estimation of lansoprazole and domperidone in combined capsule dosage form. Lansoprazole is a proton pump inhibitor and used in the treatment of duodenal and gastric ulcers and gastroesophageal reflux disease (GERD), a condition in which the acid in the stomach washes back up into the esophagus. Sometimes lansoprazole is used in combination with antibiotics to treat ulcers associated with infection caused by the H. pylori bacteria, gastro-oesophageal reflux disease (GERD), peptic ulcer and Zollinger-Ellison syndrome. Domperidone is indicated for treating symptoms associated with upper gastrointestinal motility disorders caused by chronic and sub acute gastritis. It is a gastrointestinal emptying (delayed) adjunct, a peristaltic stimulant and exhibit antiemetic properties. The mobile phase used was a combination of Acetonitrile: Methanol (81:19). The detection of the combined dosage form was carried out at 280 nm and a flow rate employed was 1 ml/min. The retention time for lansoprazole and domperidone has found to be 2.8 and 1.57 min respectively. Linearity was obtained in the concentration range of 8-24 µg/ml of lansoprazole and 8-24 µg/ml of domperidone with a correlation coefficient of 0.9977 and 0.9992. Detector consists of photodiode array detector; the reversed phase column used was RP-C18 (2.27µm size, 250 mm´4.6 mm i.d.) at ambient temperature. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of domperidone and lansoprazole in routine analysis.


Cite this article:
Bhavna Patel, Zarna Dedania, Ronak Dedania, Chetan Ramolia, G Vidya Sagar, Mehta RS. Simultaneous Estimation of Lansoprazole and Domperidone in Combined Dosage Form by RP-HPLC. Asian J. Research Chem. 2(2): April.-June, 2009 page 210-212.


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