ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): M.Sundarapandian, S.Venkataraman, R.Xavierarulappa, M.Boopathi, S.Selvakumar

Email(s): sundar2608@yahoo.co.in

DOI: Not Available

Address: M.Sundarapandian*1, S.Venkataraman2, R.Xavierarulappa2, M.Boopathi1 and S.Selvakumar2
Department of Pharmaceutical Analysis, Department of Pharmaceutical Analysis1, Department of Pharmaceutical Chemistry2 K.M.College of Pharmacy, Uthangudi, Madurai -625 107
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
A simple, rapid, economical and sensitive visible spectrophotometric method for the estimation of Meloxicam has been developed based on the formation of ion-pair of Meloxicam with dye bromocresol green in acidic medium, which was extracted into chloroform. It has absorption maxima at 415nm. Beer’s law limit was found to be 10-50mcg/ml. The molar absorptivity was found to be 2.17x103(mole-1cm-1) and sandell’s sensitivity was 0.1612 (µg/cm2/0.001 absorbance unit). The correlation coefficient (r) was found to be 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.88 and 2.69 mcg/ml respectively of Meloxicam. The result of estimation in marketed formulations was found to be 99.86±0.32 and 97.93±0.32. The proposed method was applied successfully for the determination of Meloxicam in tablets with average recovery of 99.62±0.88 and 100.4±0.768. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.


Cite this article:
M.Sundarapandian, S.Venkataraman, R.Xavierarulappa, M.Boopathi, S.Selvakumar. Spectrophotometric Determination of Meloxicam in Bulk Drug and Pharmacuetical Formulations. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 467-468.


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