ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sunakar Panda, Swapna Sankar Nayak

Email(s): swapna_nayak7@yahoo.com

DOI: Not Available

Address: 1Sunakar Panda and 2Swapna Sankar Nayak
1PG Department of Chemistry, Berhampur University, Bhanja Vihar 760007, India
2S.B.R. Govt. Women’s (Auto) College, Berhampur 760001, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
Both acridone and its semicarbazone derivative being insoluble in polar medium, may have poor pharmacological activity. To enhance bio-accessibility of these drugs, the inclusion complexes of acridone and its derivative have been prepared with ß- cyclodextrin. The spectral characteristics (UV-Vis, FTIR) of these compounds have been studied with and without inclusion complex formation. The phase solubility studies reveal 1:1 stoichiometry between guest and host. The determination of thermodynamic stability constants indicates weak intermolecular forces between the compounds and ß- cyclodextrin. The thermodynamic parameters ?G, ?H, ?S of the complexes have been calculated, the values of which suggest that complex formation is spontaneous and exothermic in nature. The antimicrobial activity of acridone and its semicarbazone derivative along with their inclusion complexes against the microbes like Escherichia coli an, Pseudomonas aeruginosa have been studied.


Cite this article:
Sunakar Panda, Swapna Sankar Nayak. Inclusion Complexes of Acridone and Its Semicarbazone Derivative With β- Cyclodextrin: - A Thermodynamic, Spectral and Antimicrobial Study. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 539-543.


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