Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Simultaneous RP-HPLC Method Development and Validation of Cefixime and Ofloxacin in Tablet Dosage Form

Author(s): Prabhu S, Vijay Amirtharaj R, Senthilkumar N

Email(s): nasiprabhu@gmail.com

DOI: Not Available

Address: Prabhu S*, Vijay Amirtharaj R and Senthilkumar N
J.K.K.Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam, Namakkal-Dt, Tamilnadu, India-638183
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010

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ABSTRACT:
A simple, precise, accurate, rapid and reproducible RP-HPLC procedure was developed for simultaneous determination of Cefixime and Ofloxacin in tablet dosage form at a single wavelength. The determination was carried out by using Phenomenox, Gemini C18, Column (50 x 4.6mm) with mobile phase used as a combination of acetonitrile : 0.05 M Tetra butyl ammonium Hydrogen Sulphate (pH 6.0 with orthophosphoric acid) (35:65). The detection of the combined dosage form was carried out at 290 nm and flow rate set 2.0 ml/min. Linearity obtained in the concentration range of 160 and 240 Cefixime and Ofloxacin with correlation coefficient of 0.9999 and 0.9999 respectively. The result of the analysis were validated statistically and recovery studies confirmed by the accuracy of the proposed method.


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Cite this article:
Prabhu S, Vijay Amirtharaj R, Senthilkumar N. Simultaneous RP-HPLC Method Development and Validation of Cefixime and Ofloxacin in Tablet Dosage Form. Asian J. Research Chem. 3(2): April- June 2010; Page 367-369.


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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