ABSTRACT:
A precise and accurate reverse phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated for estimation of quetiapine fumarate. The mobile phase consisted of methanol: water: acetonitrile (50: 40:10) was used at a flow rate of 1 ml/min and pH value of 7.0, adjusted with orthophosphosphoric acid. The detection was carried out at a wavelength of 251 nm. The developed method was found to be in accordance with ICH guidelines with respect to accuracy, precision, reproducibility, linearity and specificity.
Cite this article:
Ashish Baldi, Ashutosh Kumar Patidar, Jyotsana SanadyA. Method Development and Validation for Estimation of Quetiapine Fumarate by RP-HPLC. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 604-607.
Cite(Electronic):
Ashish Baldi, Ashutosh Kumar Patidar, Jyotsana SanadyA. Method Development and Validation for Estimation of Quetiapine Fumarate by RP-HPLC. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 604-607. Available on: https://ajrconline.org/AbstractView.aspx?PID=2010-3-3-21