ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sonal Bhale, Shyam Awate

Email(s): bhale.sonal@gmail.com

DOI: Not Available

Address: Sonal Bhale1* and Shyam Awate2
1Institute of Pharmaceutical Education and Research, Wardha-442301, Maharashtra, India
2Abhinav College of Pharmacy (B. Pharm), Narhe, Pune
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
A simple, precise, accurate, rapid and reproductive HPTLC procedure was developed for development and validation of Nitazoxanide in tablet dosage form at a single wavelength. The mobile phase used was a combination of chloroform: methanol (8:2 v/v) with 15 min time of saturation with filter paper with plate equilibrium. The detection of the combined dosage form was carried out at 330nm using 20 ×10 cm silica gel 60 f 254 TLC plate in the form of 8mm band with 14.5mm interval and migration distance allowed was 70mm. linearity was obtained in the concentration range of 5-50ug/ul of Nitazoxanide with correlation coefficients of 0.9949. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.


Cite this article:
Sonal Bhale, Shyam Awate. Development and Validation of Nitazoxanide by HPTLC in Tablet Dosage Form. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 608-610.


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