ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Vijay Kumar Tirlapur, Kashinath Noubade

Email(s): tirlapur_v@yahoo.com

DOI: Not Available

Address: Vijay Kumar Tirlapur* and Kashinath Noubade
Dept. of Pharmaceutical Chemistry, Karanataka College of Pharmacy. Manhalli Road Post Box No- 53 Bidar-585403
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
4-aminotoluidine on diazotization followed by coupling with ethylacetoacetate gave ethyl 2-[(4-methylphenyl)diazenyl]-3-oxobutanoate (2), which on condensation with substituted benzaldehydes in basic medium gave 1-[(4-methyl phenyl)diazenyl]-4-(substituted phenyl) but-3-en-2-ones (3a-e). The compound (3a-e) on reaction with urea in presence of alkali and ethanol afforded 4-(4-substituted phenyl)-6-{[(4-methylphenyl) diazenyl] methyl}-pyrimidin-2-ol (4a-e). Treatment of compound (3a-e) with hydrazine hydrate in presence of ethanol gave 5-(4-substituted phenyl)-3-{[(4-methyl phenyl) diazenyl] methyl}-4, 5-dihydro-1H pyrazole (5a-e). All newly synthesized compounds were characterized on the basis of IR, 1HNMR and mass spectral data and evaluated for antimicrobial, analgesic activities.


Cite this article:
Vijay Kumar Tirlapur, Kashinath Noubade. Synthesis, Characterization and Biological Activities of New Pyrimidines and Pyrazoles Derivative. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 659-662.


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