Asian Journal of Research in Chemistry

ISSN

0974-4150 (Online)
0974-4169 (Print)


Submit Article

Synthesis, Characterization and Biological Activities of New Pyrimidines and Pyrazoles Derivative

Author(s): Vijay Kumar Tirlapur, Kashinath Noubade

Email(s): tirlapur_v@yahoo.com

DOI: Not Available

Address: Vijay Kumar Tirlapur* and Kashinath Noubade
Dept. of Pharmaceutical Chemistry, Karanataka College of Pharmacy. Manhalli Road Post Box No- 53 Bidar-585403
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010

 View HTML        View PDF

ABSTRACT:
4-aminotoluidine on diazotization followed by coupling with ethylacetoacetate gave ethyl 2-[(4-methylphenyl)diazenyl]-3-oxobutanoate (2), which on condensation with substituted benzaldehydes in basic medium gave 1-[(4-methyl phenyl)diazenyl]-4-(substituted phenyl) but-3-en-2-ones (3a-e). The compound (3a-e) on reaction with urea in presence of alkali and ethanol afforded 4-(4-substituted phenyl)-6-{[(4-methylphenyl) diazenyl] methyl}-pyrimidin-2-ol (4a-e). Treatment of compound (3a-e) with hydrazine hydrate in presence of ethanol gave 5-(4-substituted phenyl)-3-{[(4-methyl phenyl) diazenyl] methyl}-4, 5-dihydro-1H pyrazole (5a-e). All newly synthesized compounds were characterized on the basis of IR, 1HNMR and mass spectral data and evaluated for antimicrobial, analgesic activities.


Keywords:

Cite this article:
Vijay Kumar Tirlapur, Kashinath Noubade. Synthesis, Characterization and Biological Activities of New Pyrimidines and Pyrazoles Derivative. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 659-662.

Cite(Electronic):
Vijay Kumar Tirlapur, Kashinath Noubade. Synthesis, Characterization and Biological Activities of New Pyrimidines and Pyrazoles Derivative. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 659-662.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2010-3-3-37


Recomonded Articles:

Synthesis, Characterization and Biological Study of Some Chalcones derived from Terphthaldehyde

Author(s): Suha K. Al-Mosawi, Hanan A. Al-Hazam, Abbas F. Abbas

DOI: 10.5958/0974-4150.2019.00031.2         Access: Open Access Read More

Synthesis of Some Chalcone and Their Heterocyclic Derivatives as Potential Antimicrobial Agents: A Review.

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Synthesis and antimicrobial evaluation of Azetidinone derivatives of pyridine containing hydrazides

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Schiff base metal complexes: Synthesis, Characterization, Thermal Analysis and Antibacterial Activity

Author(s): Tuly Paul, Faruk Hossen, Kudrat-E-Zahan, Masuqul Haque, Saddam Hossain, Rausan Zamir, Ali Asraf

DOI: 10.5958/0974-4150.2020.00052.8         Access: Open Access Read More

Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Review on Discovery Studio: An important Tool for Molecular Docking

Author(s): Shravani S. Pawar, Sachin H. Rohane

DOI: 10.5958/0974-4150.2021.00014.6         Access: Open Access Read More

Reduction of Schiff Bases with Sodium Borohydride Possessing Antibacterial Activity

Author(s): S.B. Junne, Archana B. Kadam, Archana Y. Vibhute, S.L. Shinde, R.B. Patil, Y.B. Vibhute

DOI:         Access: Open Access Read More

Synthesis and Biological Activities of Some Benzothiazole Derivatives

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Synthesis and Biological Evaluation of Some Substituted Amino Thiazole Derivatives

Author(s): SR Pattan, NS Dighe, SA Nirmal, AN Merekar, RB Laware, HV Shinde, DS Musmade

DOI:         Access: Open Access Read More

A Review on Pyranocoumarins and its biological importance

Author(s): K.P. Beena, G. Sathya Pooja

DOI: 10.52711/0974-4150.2022.00030         Access: Open Access Read More

Pharmacognostic and Preliminary Phytochemical Screening of Cichorium intybus Linn Seed

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Development and Validation of UV Spectrophotometric Method for Simultaneous estimation of Terbinafine hydrochloride and Mometasone furoate in Combined Dosage Form

Author(s): Heta D. Patel, Mehul M. Patel

DOI:         Access: Open Access Read More

Antibacterial Screening of Clerodendrum infortunatum leaves: Experimental and Molecular docking studies

Author(s): Sindhu. T. J, Akhilesh K. J, Anju. Jose, Binsiya K. P, Blessy Thomas, Elizabeth Wilson

DOI: 10.5958/0974-4150.2020.00026.7         Access: Open Access Read More

Oxindoles and Their Pharmaceutical Significance- An Overview

Author(s): Shashi Ravi Suman Rudrangi, Vijaya Kumar Bontha, Venkata Reddy Manda, Srinivas Bethi

DOI:         Access: Open Access Read More

Synthesis and In Vitro Antimicrobial Activity of Some New 4-Amino-N-(1,3- Benzothiazol-2-yl) benzenesulphonamide Derivatives

Author(s): KP Bhusari, ND Amnerkar, PB Khedekar, MK Kale, RP Bhole

DOI:         Access: Open Access Read More

Strategies for the Synthesis and Biological Screening of Thiazolidinone Derivatives

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Biosynthesis of Silver Nanoparticles using Medicinal Plant Anacyclus pyrethrum and its Antibacterial Efficacy

Author(s): Sapna Tyagi, Tanveer Alam, Mohd Azhar Khan, Hina Tarannum, Neha Chauhan

DOI: 10.5958/0974-4150.2018.00092.5         Access: Open Access Read More

Synthesis, spectral and biological studies of Cd (II) complex of Schiff base ligand derived from 3-hydrazinylquinoxalin-2(1H)-one and 2-hydroxy-3-methoxybenzaldehyde

Author(s): P. Sukanya, Ch. Venkata Ramana Reddy

DOI: 10.5958/0974-4150.2017.00010.4         Access: Open Access Read More

Synthesis and Characterization of N2O2 type Metal Complexes derived from 4-Aminoantipyrine, 4-Nitrobenzaldyhyde and Acetylacetone

Author(s): S.N. Ibatte

DOI: 10.5958/0974-4150.2017.00028.1         Access: Open Access Read More

A non-cytotoxic pseudo peptide KL1 with potent antioxidant activity

Author(s): Gangadhara MM, Dinesha R, Satish Kumar Murari

DOI: 10.5958/0974-4150.2017.00020.7         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Quick Links

Latest Issues

Popular Articles


Recent Articles



Activated carbon from macadamia nutshells for removal of p-Nitrophenol from real wastewater: Thermodynamic evaluation
Review on Colon Targeted Drug Delivery System
Exploring the Effects of Polyacrylic Acid on Triton-X-100 Aqueous Solutions: Density, Viscosity and Ultrasonic Velocity Analysis
Formulation and Evaluation of Amaranthus dubius herbal gel
Estimation of Imatinib Mesylate by Extractive Colorimetric Methods in Bulk and Pharmaceutical Dosage Form
Qualitative and Quantitative Analysis of the Phytochemicals in Aerva lanata
Co-Solvent effect and Kinetics of Alkaline Hydrolysis of Butyle Salicylate
A Systematic Review on Ethnobotanical and Pharmacological Aspects of Croton plant Codiaeum variegatum (L.)
Review on Thiazolo-Triazole as a Promising Anticancer agent
Inimical effects of Monosodium Glutamate on various systems
Synthesis and Surface properties of LABSA Based detergents: An Ecofriendly Approach
A mini Review on Analytical and Bioanlytical Techniques in Study of Drugs-Protein Interaction
Review on Vesicular Drug Delivery System: Aquasomes
Synthesis, Characterization and Antioxidant Activity of some New Antipyrine derived Schiff Bases
Determination of Imatinib mesylate from Pharmaceutical Dosage Form by extractive ion pair complex colorimetric Method
Coupling of Single-Stranded poly-T DNA with Small Heterocyclic compounds via Peptide Linkage
Determination of Methdilazine by Extractive Colorimetric Method from Pharmaceutical Dosage Form
Synthesis and Surface properties of AOS Based detergents: A Green Synthetic approach
Bioanalytical Method Development and Validation of UV Spectrophotometric Method for Estimation of Metformin Hydrochloride in Urine Sample
Oxovanadium (IV) Complexes of α-Amino Acid Schiff Bases and 2,2

Tags


About Journal

Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
Read More  

Visitors

Today: 861
Yesterday: 1540
Total: 1602190