Teli M.S., Sawant S.S., Kumbhoje S.R., Ravetkar A.S., Kondawar M.S.
Teli M.S.*, Sawant S.S., Kumbhoje S.R., Ravetkar A.S. and Kondawar M.S.
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli. (M.S., India.)
Volume - 3,
Issue - 3,
Year - 2010
Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities. A simple, rapid and specific method for analysis of mefenamic acid in bulk and tablet dosage form by a sensitive high-performance liquid chromatography is described. The mefenamic acid peak was developed on a C8 column by a mobile phase of acetonitrile: water. Mefenamic acid and internal standard (IS) diclofenac sodium were eluted at 3.133 and 2.750 min, respectively. The limit of quantitation and limit of detection of mefenamic acid in tablet was 0.9508 µg/ml and 0.3137 µg/ml at 288 nm. The method was linear over the range of 10-90 µg/ml with r2 of 0.99965.
Cite this article:
Teli M.S., Sawant S.S., Kumbhoje S.R., Ravetkar A.S., Kondawar M.S.. Estimation of Mefenamic Acid in Its Bulk and Tablet Formulation by
RP-HPLC Method. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 691-694.