ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): B. Syama Sundar, K. Balamuralikrishna

Email(s): profbsyamsundar@yahoo.co.in

DOI: Not Available

Address: B. Syama Sundar* and K. Balamuralikrishna
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar – 522 510 Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2011


ABSTRACT:
A simple, rapid, accurate, precise and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of Efavirenz in bulk and in pharmaceutical formulations. The quantification was carried out using Luna column C18 (250 ×4.6mm i.d., 5µm particle size) column in an isocratic mode, with mobile phase comprising a mixture of Methanol, Water and Tetrahydrofuran in a ratio of 30:50:20 (% v/v/v). The flow rate was 1.0 ml/min and the detection was carried out at 259 nm. The retention time of the drug was found to be 3.675 min and the method produced linear response in the concentration range of 20-60 µg/ml (r=0.9993). The recovery studies were also carried out and % RSD from reproducibility was found to be 0.86. The proposed method was statistically evaluated and can be applied for routine quality control analysis of Efavirenz in tablets.


Cite this article:
B. Syama Sundar, K. Balamuralikrishna. Development and Validation of New Reversed Phase High Performance Liquid Chromatography Method for the Estimation of Efavirenz in Bulk and in Pharmaceutical Dosage Forms. Asian J. Research Chem. 4(4): April, 2011; Page 555-557.


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