ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): V.V. Karkhanis, Vikas Parikh, Roma Panchal

Email(s): vesli@rediffmail.com

DOI: Not Available

Address: V.V. Karkhanis*, Vikas Parikh and Roma Panchal
A.R. College of Pharmacy and G.H. Patel institute of Pharmacy, Vallabh Vidyanagar -388 120, Dist. Anand, Gujarat
*Corresponding Author

Published In:   Volume - 4,      Issue - 8,     Year - 2011


ABSTRACT:
A simple, precise, accurate and rapid high-performance thin-layer chromatographic method has been developed for the estimation of Rosuvastatin calcium in tablet dosage forms. The stationary phase used was pre-coated silica gel 60 F254. The mobile phase used was a mixture of Acetonitrile: Ethyl Acetate: Toluene (6:1:3 v/v/v). The detection of spots was carried out at 245 nm. The calibration curve was found to be linear between 200ng/spot to 600ng/spot for Rosuvastatin calcium. The limit of detection and the limit of quantification for Rosuvastatin calcium were found to be 5.68ng/spot and 17.22ng/spot. The developed method was also validated . The method was found to be accurate, precise and reproducible and can be suitably applied for the determination of ROS in different dosage forms.


Cite this article:
V.V. Karkhanis, Vikas Parikh, Roma Panchal. Estimation of Rosuvastatin Calcium in Tablet Dosage Form by HPTLC Method. Asian J. Research Chem. 4(8): August; 2011; Page 1206-1209.


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