ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Ranjit Gadhave, Vijaya Vichare, Joshi S. V.

Email(s): ranjitgadhave@gmail.com

DOI: Not Available

Address: Ranjit Gadhave, Vijaya Vichare and Joshi S. V.
P. E. S’s, Modern College of Pharmacy (for Ladies), Borhadewadi, Dehu-Alandi Road, Moshi, Pune-412105.
*Corresponding Author

Published In:   Volume - 5,      Issue - 3,     Year - 2012


ABSTRACT:
Benzimidazole and piperazine derivatives play an important role in biological field such as antibacterial, antiviral and antifungal activity. The increasing drug resistant pathogens lent additional urgency for development of new antifungal agents. In present work N1-methyl-2-chloro benzimidazole was condensed with 1-alkyl/aryl -4-(4’-aminophenyl) piperazines to 1-methyl-2-aminophenyl-4-(N4-alkyl/arylpiperazinyl) benzimidazole derivatives. The structural elucidation of synthesized compounds is done by IR, 1H-NMR, Mass spectral analysis. Benzimidazole and piperazine derivatives synthesized are screened for their antifungal potential. The turbidimetric method is used antifungal activity against Trichophyton rubrum ATCC9029 and Candida albicans ATCC10231. The compounds showed moderate activity as compared to ketoconazole.


Cite this article:
Ranjit Gadhave, Vijaya Vichare, Joshi S. V.. Synthesis and Antifungal Screening of Novel 1-methyl-2-aminophenyl-4-(N4-alkyl/aryl piperazinyl) benzimidazole Derivatives. Asian J. Research Chem. 5(3): March 2012; Page 325-328.


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