ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): M.M. Eswarudu, T. Narendra Chary, Sunil Junapudi, M. Sushma

Email(s): eswarmunnangi@gmail.com , sunilpharma49@gmail.com

DOI: Not Available

Address: M.M. Eswarudu1*, T. Narendra Chary1, Sunil Junapudi1, M. Sushma2.
1.Department of pharmaceutical analysis, Anurag pharmacy college, Ananthagiri(V), Kodad(M), Nalgonda (Dt), Andhra Pradesh, India.508206
2.D.C.R.M. Pharmacy College, Inkollu, Prakasham Dist, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 4,     Year - 2012


ABSTRACT:
A simple, reproducible and efficient high performance liquid chromatographic method was developed for simultaneous determination of Irbesartan and Hydrochlorothiazide in tablets. A Hypersil pack BDS C18 column 250X4.6 mm 5µ particle size in isocratic mode with mobile phase containing acetonitrile: Buffer (sodium acetate anhydrous) (55:45 v/v ) adjusted to pH 3.5 using ortho phosphoric acid. The flow rate was 1.0 ml/min and effluent was monitored at 260 nm. The retention time and linearity range for Irbesartan and Hydrochlorothiazide were (2.98, 4.83 min) and (5-200, 1-400 µg/ml), respectively. The developed method was found to be accurate, precise and selective for simultaneous determination of Irbesartan and Hydrochlorothiazide in tablet dosage form.


Cite this article:
M.M. Eswarudu, T. Narendra Chary, Sunil Junapudi, M. Sushma. RP-HPLC Method Development and Validation for Simultaneous Estimation of Irbesartan and Hydrochlorothiazide in Pharmaceutical Dosage Form. Asian J. Research Chem. 5(4): April 2012; Page 472-476.


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