Author(s):
Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider
Email(s):
hinashehnaz@gmail.com
DOI:
Not Available
Address:
Hina Shahnaz1*, M. Saeed Arayne2, Najma Sultana2 and Amir Haider2
1Department of Chemistry, University of Karachi, Karachi.
2Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi.
*Corresponding Author
Published In:
Volume - 5,
Issue - 5,
Year - 2012
ABSTRACT:
Fexofenadine is a second generation H1-receptor antagonist, much widely used due to its non-sedative effects. The in vitro availability of fexofenadine in the presence of H2-receptor antagonist (cimetidine, ranitidine and famotidine) was studied on a BP 2005 dissolution test apparatus to observe the kinetics and energies of fexofenadine in the presence of H2-receptor antagonist (cimetidine, ranitidine and famotidine). These studies were carried out in buffers of pH 2, 4 (simulated gastric juice), 7.4 (blood pH) and 9 (simulated intestinal juice) at 37°C and at elevated temperatures. These studies showed that all H2-receptor antagonist (cimetidine, ranitidine and famotidine) interact to fexofenadine. Moreover, these interactions were not temperature dependent but pH dependent.
Cite this article:
Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider. In vitro Interaction of Fexofenadine with H2 Receptor Antagonist. Asian J. Research Chem. 5(5): May 2012; Page 668-677.
Cite(Electronic):
Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider. In vitro Interaction of Fexofenadine with H2 Receptor Antagonist. Asian J. Research Chem. 5(5): May 2012; Page 668-677. Available on: https://ajrconline.org/AbstractView.aspx?PID=2012-5-5-21