ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Dharti Patel, Mehul Patel, Ketan Patel

Email(s): dhartipatel0701@gmail.com

DOI: Not Available

Address: Dharti Patel*, Mehul Patel, Ketan Patel
Dept. of Pharmaceutical Quality Assurance, Ramanbhai Patel College of Pharmacy, Changa, Nadiad, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 5,     Year - 2012


ABSTRACT:
A simple, precise, specific and accurate RP- HPLC method has been developed and Validated for the simultaneous determination of Moxifloxacin Hydrochloride and Ketorolac Tromethamine in Ophthalmic dosage form. The determination was carried out by using Hypersil BDS C18 column (250mm×4.6 mm, 5µm).The Chromatographic separation was done with Acetonitrile: Buffer (pH:4) (60:40) as the mobile phase at a flow rate 1.0 ml/min and the eluent was monitored at 294nm. Buffer solution is prepared by using 0.05 mol Ammonium acetate and pH: 4 is adjusted by using OPA (Ortho Phosphoric Acid). The Retention time of Moxifloxacin Hydrochloride and Ketorolac Tromethamine were 3.54 and 5.62 respectively. Linearity for the Moxifloxacin and Ketorolac were found in the range of 10-90 µg/ml. The method was validated according to the ICH guidelines with respect to specificity, linearity (r2 = 0.998), accuracy (102 to 98%), precision and robustness (RSD < 2%). The method was reproducible, with good resolution between Moxifloxacin Hydrochloride and Ketorolac Tromethamine and can be use for routine analysis.


Cite this article:
Dharti Patel, Mehul Patel, Ketan Patel. Simultaneous RP-HPLC Estimation of Moxifloxacin Hydrochloride and Ketorolac Tromethamine in Ophthalmic Dosage Forms. Asian J. Research Chem. 5(5): May 2012; Page 697-699.


Recomonded Articles:

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy

DOI: 10.5958/0974-4150.2016.00076.6         Access: Open Access Read More

Author(s): Sravani A

DOI: 10.5958/0974-4150.2018.00144.X         Access: Open Access Read More

Author(s): Prasanna Reddy Battu, MS Reddy

DOI:         Access: Open Access Read More

Author(s): Sachin R Shinde , Suvarna I Bhoir, Namdev S Pawar, Suman B Yadav, Ajay S Ghumatkar, Ashok M Bhagwat

DOI:         Access: Open Access Read More

Author(s): Babu Ganesan, Perumal Perumal, Vijaya Baskaran Manickam, Surya Rao Srikakolapu, Srujana Divya Gotteti, Latha Sundaresan Thirumurthy

DOI:         Access: Open Access Read More

Author(s): Kathiravan S., Anbarasi B., Mathankumar S.

DOI:         Access: Open Access Read More

Author(s): Nilesh Jain, Ruchi Jain, Hemant Swami, Deepak Kumar Jain

DOI:         Access: Open Access Read More

Author(s): Ravi Pratap Pulla, B.S. Sastry, Y. Rajendra Prasad, N. Appala Raju

DOI:         Access: Open Access Read More

Author(s): Rajesh Balkrishna Tawade, Abha Sham Dhomane

DOI:         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj S. Charde, Rita M. Charde

DOI:         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Botsa Parvatamma, Karri Apparao, Jakka Mastan

DOI: 10.5958/0974-4150.2017.00059.1         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags