Amir Haider, Hina Shahnaz, M. Saeed Arayne, Najma Sultana
Amir Haider1*, Hina Shahnaz1, M. Saeed Arayne1 and Najma Sultana2
1Department of Environmental Studies, Sind Madressatul Islam (SMI) University, Karachi
2Department of Chemistry, University of Karachi, Karachi.
Volume - 5,
Issue - 8,
Year - 2012
Amantadine was discovered in petroleum and name is derived from Greek name adamantinos (relating to steel or diamond), due to its diamond-like structure. The in vitro availability of H1 and H2-receptor Antagonists, Cephalosporins, ACE-inhibitors, Hydrochlorothiazide, NSAIDs and Quinolones with Amantadine was studied on a Compact Dissolution Test Apparatus-Type PTWS 310 manufactured by Pharmatest according to USP/EP. To observe the percentage availabilities of different classes of drugs in presence of amantadine were carried out at 37?C in simulated gastric juice as it was insoluble at all other pH levels found in human body. Results reflect the possible complexation of these drugs with amantadine. The in vitro availability of all drugs was found to be markedly retarded in the presence of amantadine.
Cite this article:
Amir Haider, Hina Shahnaz, M. Saeed Arayne, Najma Sultana. In vitro Interaction of H1 and H2-receptor Antagonists, Cephalosporins, ACE-inhibitors, Hydrochlorothiazide, NSAIDs and Quinolones with Amantadine. Asian J. Research Chem. 5(8): August, 2012; Page 1017-1024.