ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Ramakrishna K., Rebecca Shiffali D., Pani Kumar A.D.

Email(s): rkkommana@gmail.com

DOI: Not Available

Address: Ramakrishna K.*, Rebecca Shiffali D., Pani Kumar A.D.
Department of Pharmaceutical Analysis and Quality Assurance, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad-500 090 Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 6,      Issue - 2,     Year - 2013


ABSTRACT:
Two simple, selective, rapid, accurate, precise and cost-effective spectrophotometric methods for the determination of Pioglitazone Hydrochloride in bulk drug and in tablets have been developed and validated. In the first method (method A), hydrotropic solution of citric acid (0.1M) was employed as solubilizing agent to solubilize pioglitazone hydrochloride (poorly water soluble drug) fine powder and its tablet dosage form for spectrophotometric determination in UV region (hydrotropic technique). The maximum absorbance of pioglitazone hydrochloride in 0.1M citric acid solution by hydrotropic technique was found to be at 269 nm. The second method (method B) is based on the reaction of 3- methylbenzothiazolin-2-one hydrazone (MBTH) with pioglitazone hydrochloride in the presence of ferric chloride (oxidative-coupling reaction). The resulting green colored chromogen complex absorbs at ? (Lambda) max 667 nm. Beer’s law was obeyed over the ranges 4-34, 5-35 µg/mL for method A and method B respectively. The limit of detection (LOD), limit of quantification (LOQ) and sandell’s sensitivity values are reported. Both the methods were validated in accordance with ICH guidelines. The results of the analysis have been validated statistically. The methods have been successfully applied in the analysis of marketed formulations. No significant interference was observed from either hydrotropic agent or commonly used tablet additives with the assay procedure.


Cite this article:
Ramakrishna K., Rebecca Shiffali D., Pani Kumar A.D.. Estimation of Pioglitazone Hydrochloride in Bulk Drug and Pharmaceutical Dosage Forms by Hydrotropy Technique and Oxidative-Coupling Reaction. Asian J. Research Chem. 6(2): February 2013; Page 172-176.


Recomonded Articles:

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): R.K. Nanda, S.E. Potawale, V.V. Bhagwat, S.C.Hamane, R. S. Deshmukh

DOI:         Access: Open Access Read More

Author(s): VB Kshirsagar, UA Deokate, VB Bharkad, SS Khadabadi

DOI:         Access: Open Access Read More

Author(s): S. Ganapathy, G.V.H. Raju, D.G. Sankar, Pettla Y. Naidu

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags