ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Deepa Parashar, Ankush Kumar, N.P. Aditya, Ramachandra Murthy Rayasa

Email(s): m_rsr@rediffmail.com

DOI: Not Available

Address: Deepa Parashar1, Ankush Kumar1, N.P. Aditya2, Ramachandra Murthy Rayasa1*
1I.S.F. College of Pharmacy, Ferozpur, G.T. Road, Moga, Punjab, India
2Food Nanotechnology Laboratory, Department of Food science and Technology, Sejong University, Seoul, South Korea
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2013


ABSTRACT:
In the present investigation a simple, rapid and accurate method for the simultaneous estimation of artemether (ART) and lumefantrine (LUM) was developed using derivative spectroscopic technique. To avoid the overlapping of ART and LUM in zero order spectra, first order spectrum was developed. ART showed good linearity with regression coefficient (r2) of 0.9993 over the range of 30-80µg/ml at 260 nm wavelength and LUM showed linearity over the range of 4-12µg/ml at 286.2 nm wave length with correlation coefficient (r2 ) of 0.9999. The analytical method was validated for simultaneous estimation of ART and LUM both as drug solutions, in tablets and in NLCs and validation parameters are reported. Intercept value of the linear lines determined for ART and LUM were nearly zero. ART and LUM showed accuracy of 99.215 and 99.564 in terms of % recovery. The relative standard deviation (RSD at n=6) intra-day: Inter-day precision for ART and LUM were 0.944:1.124 and 0.890:1.009 respectively indicating the method is precise. LOD (µg/ml) and LOQ (µg/ml) values for ART were 0.3606 and 1.0928 and for LUM were 0.1145 and 0.3470 respectively. The developed method was successfully applied in the estimation of ART and LUM in commercial tablet (Arte plus CD) containing both the drugs.


Cite this article:
Deepa Parashar, Ankush Kumar, N.P. Aditya, Ramachandra Murthy Rayasa. Simultaneous Estimation of Artemether and Lumefantrine in Pharmaceutical dosage forms using Derivative Spectrophotometry. Asian J. Research Chem. 6(3): March 2013; Page 226-231.


Recomonded Articles:

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): R.K. Nanda, S.E. Potawale, V.V. Bhagwat, S.C.Hamane, R. S. Deshmukh

DOI:         Access: Open Access Read More

Author(s): Mukund Nagarnaik, Arun Sarjoshi, Ajay Bodkhe, Bhupendra Khanal, Mayuri Pise, Girish Pandya

DOI: 10.5958/0974-4150.2015.00102.9         Access: Open Access Read More

Author(s): VB Kshirsagar, UA Deokate, VB Bharkad, SS Khadabadi

DOI:         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy

DOI: 10.5958/0974-4150.2016.00076.6         Access: Open Access Read More

Author(s): Prasanna Reddy Battu, MS Reddy

DOI:         Access: Open Access Read More

Author(s): J Vanitha, A Saravana Kumar, M Ganesh, VS Saravanan

DOI:         Access: Open Access Read More

Author(s): Nilesh Jain, Ruchi Jain, Hemant Swami, Deepak Kumar Jain

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags