ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Chinnalalaiah Runja, Ravikumar Pigili

Email(s): drpigili@gmail.com

DOI: Not Available

Address: Chinnalalaiah Runja and Ravikumar Pigili*
Department of Pharmaceutical Chemistry, Joginpally B R Pharmacy College, Moinabad, R.R Dist., Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 4,     Year - 2013


ABSTRACT:
A New RP-HPLC method was developed and validated for estimation of rilpivirine hydrochloride. A simple, selective, precise, accurate and robust method was developed and validated according to the ICH guidelines for the estimation of Rilpivirine hydrochloride in bulk and tablet dosage form. The method developed is more simple, robust and accurate than the existing methods. The estimation was carried out on C18 column (150 x 4.6 mm, 5m) using Phosphate Buffer (pH 6.0): Methanol: Acetonitrile in the ration of 40:5:55 (v/v) as mobile phase. The flow rate was 1.2 ml/min and the effluent was monitored by PDA detector at 280 nm. The retention time was 4.74 and Linearity was observed in the concentration range of 25–150 µg mL-1 with regression equation y = 34443x - 8259.4 (R² = 0.9997). The mean % recovery obtained is 98.6%. The percentage recovery was in good agreement with the labeled amount in the pharmaceutical formulations and the method is simple, precise, accurate and robust for the determination of rilpivirine hydrochloride in pharmaceutical formulations.


Cite this article:
Chinnalalaiah Runja, Ravikumar Pigili. A Validated RP-HPLC Method for Estimation of Rilpivirine in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 6(4): April 2013; Page 319-322 .


Recomonded Articles:

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): S. Ganapathy, G.V.H. Raju, D.G. Sankar, Pettla Y. Naidu

DOI:         Access: Open Access Read More

Author(s): Prasanna Reddy Battu, MS Reddy

DOI:         Access: Open Access Read More

Author(s): J Vanitha, A Saravana Kumar, M Ganesh, VS Saravanan

DOI:         Access: Open Access Read More

Author(s): Babu Ganesan, Perumal Perumal, Vijaya Baskaran Manickam, Surya Rao Srikakolapu, Srujana Divya Gotteti, Latha Sundaresan Thirumurthy

DOI:         Access: Open Access Read More

Author(s): Nilesh Jain, Ruchi Jain, Hemant Swami, Deepak Kumar Jain

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags