ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Jyoti Rai, Sunil Singh, Inamullah, Nisha Choudhary, Surabhi Sharma, Hemendra Gautam

Email(s): rssunil29@rediffmail.com

DOI: Not Available

Address: Jyoti Rai, Sunil Singh*, Inamullah, Nisha Choudhary, Surabhi Sharma, Hemendra Gautam
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly (U.P.)
*Corresponding Author

Published In:   Volume - 6,      Issue - 8,     Year - 2013


ABSTRACT:
A new stability indicating absorption ratio method was developed and validated for the determination of Esomeprazole magnesium (ESO) and Domperidone (DOM) in capsule dosage form. The maximum wavelength (?max) was found to be 299nm for ESO and 287nm for DOM. The iso-absorptive point of both the drug was found to be 290 nm. The linearity range was found to be 1-6 µg ml-1(r2= 0.998) and 5-30 µg ml-1(r2= 0.999) for ESO and DOM respectively. The value of limit of detection and limit of quantification was 0.116µgml-1 and 0.386µgml-1 for ESO and 0.657µgml-1 and 2.18µgml-1 for DOM respectively. Forced degradations were carried out under acid, base, thermal, photolytic and oxidative stress conditions. The method was satisfactorily validated as per ICH guideline. The result of study showed that the proposed spectrophotometric method is useful for the routine determination of ESO and DOM in its combined pharmaceutical dosage form.


Cite this article:
Jyoti Rai, Sunil Singh, Inamullah, Nisha Choudhary, Surabhi Sharma, Hemendra Gautam. Stability Indicating Absorption Ratio Method for Determination of Domperidone and Esomeprazole Magnesium in Capsule Dosage Form Using UV-Spectrophotometer. Asian J. Research Chem. 6(8): August 2013; Page 735-739.


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DOI: 10.5958/0974-4150 

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