ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): M.Karpakavalli, T. Sivakumar

Email(s): sreemenakag@gmail.com , sivaecp@yahoo.com

DOI: Not Available

Address: M.Karpakavalli1*, T. Sivakumar2
1Associate Professor, Dept. of Pharmaceutical Chemistry, Karpagam Collage of Pharmacy, Coimbatore-641032, Tamilnadu, India
2Principal, Dept. of Pharmaceutical Chemistry, Nanda Collage of Pharmacy, Perundurai-638052, Tamilnadu, India
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2014


ABSTRACT:
A new technique of “Microwave Enhanced Chemistry and Diaza Bicyclo Undecene (MEC-DBU)”a popular ionic liquid catalyst, is made use of in the synthesis of various nitro, dinitro and acetyl derivatives of 7-flavanols from Resacetophenones and acyl chlorides by Bayer-Venkatraman rearrangement mechanism followed by microwave irradiated hetero-cyclization of the intermediately formed diketones. The products were characterized by TLC, IR, 1HNMR and mass spectral studies. All the synthesized compounds were screened for their potency against bacteria and fungi by disc diffusion method in comparison to Amikacin and Ketoconazole respectively. Their anti-inflammatory activity was studied by in-vitro protein denaturation method and anti-oxidant studies were studied by three in-vitro methods including Hydrogen peroxide method, Nitric oxide assay and Alkaline DMSO method and it was found to be that all the compounds except the unsubstituted flavonols, gave an equi- or more potent activity as compared to that of the standard.


Cite this article:
M.Karpakavalli, T. Sivakumar. Synthesis, Characterization and Pharmacological Activities of 7- Flavonol Derivatives obtained by an Expeditious Coupling Technique of Microwave Irradiations and Ionic Liquid. Asian J. Research Chem. 7(2): February 2014; Page 148-158.

Cite(Electronic):
M.Karpakavalli, T. Sivakumar. Synthesis, Characterization and Pharmacological Activities of 7- Flavonol Derivatives obtained by an Expeditious Coupling Technique of Microwave Irradiations and Ionic Liquid. Asian J. Research Chem. 7(2): February 2014; Page 148-158.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2014-7-2-8


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