0974-4150 (Online)
0974-4169 (Print)

Author(s): Ashish Mullani, J. I. Disouza


DOI: 10.5958/0974-4150.2015.00089.9   

Address: Ashish Mullani*, J. I. Disouza
Shri Jagdishprasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan – 333001
*Corresponding Author

Published In:   Volume - 8,      Issue - 9,     Year - 2015

A series of N-substituted [5-(1H-1,2,4-triazol-5-yl)pyridine-2-yl]methanimine were synthesized by condensing 5-(1H-1,2,4-triazol-5-yl)pyridin-2-amines with various aromatic aldehydes. The structures of these newly synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral studies. All the compounds were screened for their antibacterial activities. The QSAR studies were performed on V Life MDS 4.3 software. QSAR equation revealed that selected electronic, steric and liphophillic parameters have correlation with antibacterial activity. Best equations were selected on basis of correlation coefficient (r2) and predictiivity of equation. The frequent appearance of lipophilic and topological descriptors in the QSAR equations is indicative of lipophilic and steric parameters are the prerequisites for molecules to exhibit activity against bacteria.

Cite this article:
Ashish Mullani, J. I. Disouza. Synthesis and QSAR study of N-Substituted [5-(1H-1,2,4-Triazol-5-yl)pyridine-2-YL]methanimine Derivatives as potential Antibacterial. Asian J. Research Chem. 8(9): September 2015; Page 561-565. doi: 10.5958/0974-4150.2015.00089.9

Recomonded Articles:

Author(s): Gullipilli Sandhya, R. Ravichandra Babu

DOI: 10.5958/0974-4150.2018.00115.3         Access: Open Access Read More

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Closed Access Read More

Author(s): Bhavna V. Mohite

DOI:         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles

Recent Articles