ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Ashish Mullani, J. I. Disouza

Email(s): ashishmullani82@gmail.com

DOI: 10.5958/0974-4150.2015.00089.9   

Address: Ashish Mullani*, J. I. Disouza
Shri Jagdishprasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan – 333001
*Corresponding Author

Published In:   Volume - 8,      Issue - 9,     Year - 2015


ABSTRACT:
A series of N-substituted [5-(1H-1,2,4-triazol-5-yl)pyridine-2-yl]methanimine were synthesized by condensing 5-(1H-1,2,4-triazol-5-yl)pyridin-2-amines with various aromatic aldehydes. The structures of these newly synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral studies. All the compounds were screened for their antibacterial activities. The QSAR studies were performed on V Life MDS 4.3 software. QSAR equation revealed that selected electronic, steric and liphophillic parameters have correlation with antibacterial activity. Best equations were selected on basis of correlation coefficient (r2) and predictiivity of equation. The frequent appearance of lipophilic and topological descriptors in the QSAR equations is indicative of lipophilic and steric parameters are the prerequisites for molecules to exhibit activity against bacteria.


Cite this article:
Ashish Mullani, J. I. Disouza. Synthesis and QSAR study of N-Substituted [5-(1H-1,2,4-Triazol-5-yl)pyridine-2-YL]methanimine Derivatives as potential Antibacterial. Asian J. Research Chem. 8(9): September 2015; Page 561-565. doi: 10.5958/0974-4150.2015.00089.9


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DOI: 10.5958/0974-4150 

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