ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Virupakshi Prabhakar, K. Sudhakar Babu, . L. K. Ravindranath, B.Venkateswarlu

Email(s): virupakshi.prabhakar@gmail.com

DOI: 10.5958/0974-4150.2017.00035.9   

Address: Dr. Virupakshi Prabhakar1*, Prof. K. Sudhakar Babu2, Prof. L. K. Ravindranath2, Dr B.Venkateswarlu3
1Faculty of Engineering Chemistry, SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Kurnool (Dist), A.P., India.
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A.P.) India.
3Faculty of Engineering Chemistry, PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.) India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 2,     Year - 2017


ABSTRACT:
A series of novel 4-Substituted/Heterocyclic-N-(4-thiomorpholinothieno[3,2-d]pyrimidin-2-yl)benzamide (8a-j)derivatives were synthesized by a Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis)from Gram positive group of bacteria and Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli)from Gram negative group of bacteria and antifungal activity against Aspergillus niger (A. niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin and Flucanazole From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 8j, 8i, 8e and 8fpossess good activity.


Cite this article:
Virupakshi Prabhakar, K. Sudhakar Babu, . L. K. Ravindranath, B.Venkateswarlu. Synthesis and Biological Activities of Novel Thieno [3, 2-d] Pyrimidine Derivatives. Asian J. Research Chem. 2017; 10(2):206-216. doi: 10.5958/0974-4150.2017.00035.9


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