0974-4150 (Online)
0974-4169 (Print)

Author(s): Souhaila Meneceur, Mohammed Ridha Ouahrani, Salah Eddine Laouini, Rachida Zouari Ahmed, Abderrhmane Bouafia


DOI: 10.5958/0974-4150.2020.00071.1   

Address: Souhaila Meneceur1, Mohammed Ridha Ouahrani1, Salah Eddine Laouini2, Rachida Zouari Ahmed1, Abderrhmane Bouafia2*
1Department of Chemistry, Faculty of Exact Sciences, University of Echahid Hamma Lakhdar, El-Oued, 39000, Algeria.
2Department of Process Engineering, Faculty of Technology, University of Echahid Hamma Lakhdar, El Oued 39000, Algeria.
*Corresponding Author

Published In:   Volume - 13,      Issue - 5,     Year - 2020

In Algeria and like many other countries of the world and in the absence of other effective therapeutic remedies. Antidepressant serum remains the only way to neutralize these toxins and fight these disorders despite sometimes-unsatisfactory results. In order to contribute subsidize to the improvement of these results; we considered it useful to study the factors influencing the composition and the concentration of the toxins to know the behavior of the antiscorpionic serum on these toxins. To do this, we tested the ability of polyspecific antisorpional serum and determined whether enough antivenom was administered. Comparative titrations were performed separately on the venoms of female scorpions (Androctonus australis hoctor, Buthacus arenicola and Androctonus Amoreuxi) caught in three different geographical region in El Oued: Debila, Reguiba and Hassi Khalifa.

Cite this article:
Souhaila Meneceur, Mohammed Ridha Ouahrani, Salah Eddine Laouini, Rachida Zouari Ahmed, Abderrhmane Bouafia. The Verification of the Efficacity of the Polyspecific Antisorpionic Serum against Three Scorpion in El Oued Region. Asian J. Research Chem. 2020; 13(5):376-382. doi: 10.5958/0974-4150.2020.00071.1

1.    Devaux C, Jouirou B, Krifi MN, Clot-Faybesse O, El Ayeb M, Rochat H. Quantitative variability in the biodistribution and in toxinokinetic studies of the three main alpha toxins from the Androctonus australis hector scorpion venom. Toxicon. 2004; 43(6):661-9.
2.    Krifi MN, Amri F, Kharrat H, El Ayeb M. Evaluation of antivenom therapy in children severely envenomed by Androctonus australis garzonii (Aag) and Buthus occitanus tunetanus (Bot) scorpions. Toxicon. 1999; 37(11):1627-34.
3.    Namasivayan C, Selvaraj S, Kameshwari V, Nimmy A, Sundaramoorthy S. A Pharmacological Review on Achyranthes aspera. Research Journal of Pharmacology and Pharmacodynamics. 2019; 11(4):159-64.
4.    Jose N. Bee Venom Therapy (BVT). Asian Journal of Nursing Education and Research. 2015; 5(2):293-6.
5.    Prabhakaran A, Kumaravel P, Priya J, Melchias G, Edward A, Sridevi G. Investigation of antibacterial and haemolytic activity of Russell's viper and Echis carinatus venom. Asian Journal of Pharmaceutical Analysis. 2014; 4(1):1-4.
6.    Sivakumar S, Manju P. Identification of new snake venom zinc Metalloproteinase inhibitor using docking studies from Plectanthus amboinicus. Asian Journal of Research in Pharmaceutical Science. 2017; 7(3):132-4.
7.    John L. Anti Snake Venom. International Journal of Nursing Education and Research. 2018; 6(4):423-4.
8.    Maheswari C, Venkatnarayanan R, Babu P, Kanadasamy C. In vivo Anti-Snake venom activity of methanol extract of leaves of Orthosiphon stamineus in mice. Research Journal of Pharmacology and Pharmacodynamics. 2014; 6(3):126-8.
9.    Warell D. Animal poisons in Masson’s tropical diseases. Masson Pec. Bahr. Bell DR. eds. London; 1987.
10.    Ismail M, Abd-Elsalam M, Al-Ahaidib M. Androctonus crassicauda (Olivier), a dangerous and unduly neglected scorpion—I. Pharmacological and clinical studies. Toxicon. 1994; 32(12):1599-618.
11.    Sivaraman T, Sreedevi N, Meenatchisundaram S. Identification and Quantification of antivenom compounds from aqueous extract of Cyclea peltata root. Research Journal of Pharmacy and Technology. 2018; 11(4):1386-90.
12.    Astaraki P, Basati G, Abbaszadeh S, Mahmoudi GA. A Review of medicinal plants used for snakebites and scorpion stings in Iran: A systematic review. Research Journal of Pharmacy and Technology. 2020; 13(3):1565-9.
13.    Prasad R, Kumar A, Mishra OP, Singh TB, Singh A. Efficacy of Scorpion Antivenom in Grade III and IV Scorpion Envenomation. The Indian Journal of Pediatrics. 2018; 85(7):576-.
14.    Bond GR. Antivenin administration for Centruroides scorpion sting: risks and benefits. Annals of emergency medicine. 1992; 21(7):788-91.
15.    Ismail M. The treatment of the scorpion envenoming syndrome: the Saudi experience with serotherapy. Toxicon. 1994; 32(9):1019-26.
16.    Ismail M. Treatment of the scorpion envenoming syndrome: 12-years-experience with serotherapy. International journal of antimicrobial agents. 2003; 21(2):170-4.
17.    Tarasiuk A, Menascu S, Sofer S. Antivenom serotherapy and volume resuscitation partially improve peripheral organ ischemia in dogs injected with scorpion venom. Toxicon. 2003; 42(1):73-7.
18.    El-Amin E, Sultan O, Al-Magamci M, Elidrissy A. Serotherapy in the management of scorpion sting in children in Saudi Arabia. Annals of tropical paediatrics. 1994; 14(1):21-4.
19.    Freire-Maia L, Campos J, Amaral C. Approaches to the treatment of scorpion envenoming. Toxicon. 1994; 32(9):1009-14.
20.    Krifi MN, Savin S, Debray M, Bon C, El Ayeb M, Choumet V. Pharmacokinetic studies of scorpion venom before and after antivenom immunotherapy. Toxicon. 2005; 45(2):187-98.
21.    Bawaskar H, Bawaskar P. Treatment of cardiovascular manifestations of human scorpion envenoming: is serotherapy essential? The Journal of tropical medicine and hygiene. 1991; 94(3):156-8.
22.    Sofer S, Shahak E, Gueron M. Scorpion envenomation and antivenom therapy. The Journal of pediatrics. 1994; 124(6):973-8.
23.    Badr A, Abderrahman E, Hassan A, Mina AE, Rachid E, Yassir B. Epidemiological profile of snakebites cases recorded at the 3rd military hospital laayoune morocco between 2011 and 2017. Research Journal of Pharmacy and Technology. 2018; 11(5):1752-6.
24.    Mohammed ZI, Hassan AJ. Effect of Bee venom on gene expression of HSP70 and IL-1β in male rats induced by arthritis in comparison with Prednisolone drug. Research Journal of Pharmacy and Technology. 2019; 12(11):5269-74.
25.    Gopalakrishnakone P, Cheah J, Gwee M. Black scorpion (Heterometrus longimanus) as a laboratory animal: maintenance of a colony of scorpion for milking of venom for research, using a restraining device. Laboratory animals. 1995; 29(4):456-8.
26.    Gwee MC, Wong PT-H, Gopalakrishnakone P, Cheah L, Low KS. The black scorpion Heterometrus longimanus: pharmacological and biochemical investigation of the venom. Toxicon. 1993; 31(10):1305-14.
27.    Possani L, Fletcher P, Fletcher M, Rode G, Mochca-Morales J, Lucas S, et al. Structural and functional characteristics of toxins purified from the venom of the Brazilian scorpion Tityus serrulatus Lutz and Mello. Mem Inst Butantan. 1992; 54(2):35-52.
28.    Schwartz EF, Camargos TS, Zamudio FZ, Silva LP, Bloch Jr C, Caixeta F, et al. Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum. Toxicon. 2008; 51(8):1499-508.
29.    Rodríguez-Ravelo R, Coronas FI, Zamudio FZ, González-Morales L, López GE, Urquiola AR, et al. The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas. Journal of venomous animals and toxins including tropical diseases. 2013; 19(1):13.
30.    Ozkan O, Kar S, Güven E, Ergun G. Comparison of proteins, lethality and immunogenic compounds of Androctonus crassicauda (Olivier, 1807) (Scorpiones: Buthidae) venom obtained by different methods. Journal of Venomous Animals and Toxins including Tropical Diseases. 2007; 13(4):844-56.
31.    Zlotkin E, Gordon D. Detection, purification and receptor binding assays of insect selective neurotoxins derived from scorpion venoms. Neurochemical techniques in insect research: Springer; 1985: pp. 243-95.
32.    Oukkache N, Chgoury F, Lalaoui M, Cano AA, Ghalim N. Comparison between two methods of scorpion venom milking in Morocco. Journal of venomous animals and toxins including tropical diseases. 2013; 19(1):5.
33.    Turner R. Screening methods in pharmacology: Elsevier. 2013.
34.    Chinedu E, Arome D, Ameh FS. A new method for determining acute toxicity in animal models. Toxicology international. 2013; 20(3):224.
35.    O'Leary MA, Isbister G. Detection of venom–antivenom (VAV) immunocomplexes in vitro as a measure of antivenom efficacy. Toxicon. 2014; 77:125-32.

Recomonded Articles:

Author(s): M. Govindammal, M. Prasath, B. Sathya, M. Selvapandiyan

DOI: 10.5958/0974-4150.2017.00079.7         Access: Open Access Read More

Author(s): Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Kavitha.K, Nehla Yahoob, Vijayakumar. B,Reshma Fathima.K

DOI: 10.5958/0974-4150.2017.00096.7         Access: Open Access Read More

Author(s): Biplab De, Sandip Sen, T.S. Easwari

DOI:         Access: Open Access Read More

Author(s): Vipul Singh, Arvind Kumar Singh, Rohit Tripathi, Preeti Mishra, Roopes Kumar Maurya

DOI:         Access: Open Access Read More

Author(s): Nachiket S. Dighe, Ravindra B. Saudagar, Ramesh S. Kalkotwar, D.A. Jain

DOI:         Access: Open Access Read More

Author(s): Nachiket S. Dighe, Renuka N.Barhate, Ravindra B. Lawre, Sunil A. Nirmal

DOI: 10.5958/0974-4150.2015.00120.         Access: Open Access Read More

Author(s): Souhaila Meneceur, Mohammed Ridha Ouahrani, Salah Eddine Laouini, Rachida Zouari Ahmed, Abderrhmane Bouafia

DOI: 10.5958/0974-4150.2020.00071.1         Access: Closed Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles

Recent Articles