ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Tariqul Islam, Nur Amin Bitu, Faruk Hossen, Ali Asraf, Kudrat-E-Zahan

Email(s): kudrat.chem@ru.ac.bd

DOI: 10.52711/0974-4150.2024.00002   

Address: Tariqul Islam, Nur Amin Bitu, Faruk Hossen, Ali Asraf, Kudrat-E-Zahan*
Department of Chemistry, Rajshahi University, Rajshahi - 6205, Bangladesh.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
A Schiff base ligand was synthesized via the condensation reaction of thiosemicarbazide and salicylaldehyde. A series of transition metal complexes of VO(IV), Ni(II), Cu(II), and Zn(II) were obtained by the complexation reaction with the synthesized Schiff base ligand. The Schiff base ligand and its metal complexes were characterized by UV-Vis and FTIR spectroscopy, TGA-DTA, and some physical measurements. FTIR spectral studies showed that the NOS donor ligand coordinated to the metal ions through the N of azomethine group, S of thiolate, and O of deprotonated hydroxyl group. Molar conductance values indicated non electrolytic nature of the complexes. Magnetic moment values coupled with electronic spectral data exhibited the geometrical structure of the complexes. The Schiff base and its complexes were exposed to disinfectant studies tested by using the disc diffusion method. All the synthesized compounds exhibited moderate to strong antibacterial activity. The copper complexes showed more antibacterial activity than other complexes and Schiff bases. All the Synthesized complexes showed a good cytotoxic activity.


Cite this article:
Tariqul Islam, Nur Amin Bitu, Faruk Hossen, Ali Asraf, Kudrat-E-Zahan. Investigation on Biological Activities of Thiosemicarbazide Derived Schiff Base-Metal Complexes. Asian Journal of Research in Chemistry. 2024; 17(1):6-2. doi: 10.52711/0974-4150.2024.00002

Cite(Electronic):
Tariqul Islam, Nur Amin Bitu, Faruk Hossen, Ali Asraf, Kudrat-E-Zahan. Investigation on Biological Activities of Thiosemicarbazide Derived Schiff Base-Metal Complexes. Asian Journal of Research in Chemistry. 2024; 17(1):6-2. doi: 10.52711/0974-4150.2024.00002   Available on: https://ajrconline.org/AbstractView.aspx?PID=2024-17-1-2


REFERENCES:
1.    N. Mohammad, E. Uddin, S. Uddin, I. H. Babar, S.  Hossain, N.  A. Bitu, M. N. Khan, A. Asraf, F. Hossen, and M. Kudrat-E-Zahan. Exploring Schiff Base Chemistry-An overview. International Journal of Chemistry and Pharmaceutical Sciences. 2021; 9(1): 18–31.
2.    M. G. Abd, E. Wahed, E. M. Nour, S. Teleb, and S. Fahim. Thermodynamic and thermal investigation of Co(II), Ni(II) and Cu(II) complexes with adenine.  Journal of Thermal Analysis and Calorimetry. 2004; 76: 343–348.
3.    M. M. Omar, G. G. Mohamed, and A. A. Ibrahim. Spectroscopic characterization of metal complexes of novel Schiff base. Synthesis, thermal and biological activity studies.  Spectrochim Acta A Mol Biomol Spectrosc. 2009; 73(2): 358–369. https://doi.org/10.1016/j.saa.2009.02.043
4.    A. K. Mishra, N. Manav, and N. K. Kaushik, ‘Organotin(IV) complexes of thiohydrazones: Synthesis, characterization and antifungal study’, Spectrochim Acta A Mol Biomol Spectrosc. 2005;  61(13–14): 3097–3101. https://doi.org/10.1016/j.saa.2004.11.035
5.    M. D. Altntop, A. Ozdemir, G. Turan-Zitouni, S. Ilgın, O. Atlı, G. Iscan, and Z. A. Kaplancıklı. Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents. European Journal of Medicinal Chemistry. 2012; 58: 299–307.  https://doi.org/10.1016/j.ejmech.2012.10.011
6.    D. Mishra, S. Naskar, M. G. B. Drew, and S. K. Chattopadhyay. Mononuclear and binuclear ruthenium (II) complexes with 4-(phenyl) thiosemicarbazone of benzaldehyde: A discussion on the relative stabilities of the four-membered and five-membered chelate rings formed by the ligand.  Polyhedron. 2005; 24(14): 1861–1868. https://doi.org/10.1016/j.poly.2005.05.018
7.    R. P. Tenório, C. S. Carvalho, C. S. Pessanha, J. G. de Lima, A. R. de Faria, A. J. Alves, E. J. T. de Melob, and A. J. S. Goes. Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity.  Bioorganic and Medicinal Chemistry Letters. 2005; 15(10): 2575–2578.  https://doi.org/10.1016/j.bmcl.2005.03.048
8.    N. Raman, A. Selvan, and P. Manisankar. Spectral, magnetic, biocidal screening, DNA binding and photocleavage studies of mononuclear Cu(II) and Zn(II) metal complexes of tricoordinate heterocyclic Schiff base ligands of pyrazolone and semicarbazide/ thiosemicarbazide based derivatives. Spectrochim Acta A: Molecular and Biomolecular Spectroscopy. 2010; 76(2): 161–173. https://doi.org/10.1016/j.saa.2010.03.007
9.    S. N. Pandeya, D. Sriram, G. Nath, and E. Declercq. Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(49-chlorophenyl) thiazol-2-yl] thiosemicarbazide. European Journal of Pharmaceutical Science. 1999; 9(1): 25-31. https://doi.org/10.1016/s0928-0987(99)00038-x
10.    S. M. S. Shariar, M. Jesmin, and M. M. Ali. Antibacterial Activities of Some Schiff Bases Involving Thiosemicarbazide and Ketones. International Letters of Chemistry, Physics and Astronomy. 2014; 26: 53–61. https://doi.org/10.18052/www.scipress.com/ilcpa.26.53
11.    E. Pahontu, F. Julea, T. Rosu, V. Purcarea, Y. Chumakov, P. Petrenco, and A. Gulea. Antibacterial, antifungal and in vitro antileukaemia activity of metal complexes with thiosemicarbazones. Journal of Cellular and Molecular Medicine. 2015; 19(4):  865–878. https://doi.org/10.1111/jcmm.12508
12.    M. B.  Ferrari, S. Capacchi, G. Reffo, G. Pelosi, P. Tarasconi, R. Albertini, S. Pinelli and P. Lunghi. Synthesis, structural characterization and biological activity of p-fluorobenzaldehyde thiosemicarbazones and of a nickel complex.  Journal of Inorganic Biochemistry. 2000; 81: 89-97. https://doi.org/10.1016/S0162-0134(00)00087-8
13.    M. S. Hossain, C. M. Zakaria, B. Zaman and M. Kudrat-E-Zahan. Synthesis, Spectral and Thermal Characterization of Cu (II) Complexes with Two New Schiff Base Ligand towards Potential Biological Application’. Der Chemica Sinica, 2017; 8(3): 80-392.
14.    M. N. A. Bitu, M. S. Hossain, A. A. S. M. Zahid, C. M. Zakaria and M. Kudrat-E-Zahan. Anti-pathogenic Activity of Cu (II) Complexes Incorporating Schiff Bases: A Short Review.  American Journal of Heterocyclic Chemistry. 2019; 5(1): 11. https://doi.org/10.11648/j.ajhc.20190501.14
15.    H. Beraldo and D. Gambino. The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarba-zones and Their Metal Complexes.  Medicinal Chemistry. 2004; 4(1): 31-39, 2004. https://doi.org/10.2174/13895570434874842004
16.    D. Kovala-Demertzi, M. A. Demertzis, J. R. Miller, C. Papadopoulou, C. Dodorou, and G. Filousis. Platinum (II) complexes with 2-acetyl pyridine thiosemicarbazone Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity.  Journal of Inorganic Biochemistry. 2001; 86(2-3): 555-63. https://doi.org/10.1016/s0162-0134(01)00224-0
17.    M. A. Asraf, D. Sarker, M. F. Hossen, M. M. Haque, and M. Kudrat-E-Zahan. Molecular Computation and Antibacterial Activity of Cu (II) Complex of Naphthaldehyde Thiosemicarbazone. American Journal of Pure and Applied Biosciences. 2020; 85–93. https://doi.org/10.34104/ajpab.020.085093
18.    R. S. Keri, K. Chand, S. Budagumpi, S. B. Somappa, S. A. Patil, and B. M. Nagaraja. An overview of benzo[b]thiophene-based medicinal chemistry.  European Journal of Medicinal Chemistry. 2017; 138: 1002–1033. https://doi.org/10.1016/j.ejmech.2017.07.038
19.    S. Chandra, S. Bargujar, R. Nirwal, and N. Yadav. Synthesis, spectral characterization and biological evaluation of copper (II) and nickel (II) complexes with thiosemicarbazones derived from a bidentate Schiff base. Spectrochim Acta A: Molecular and Biomolecular Spectroscopy. 2013; 106: 91–98. https://doi.org/10.1016/j.saa.2012.12.014
20.    S. Savir, J. W. K. Liewb, I. Vythilingamb, Y. A. L. Limb, C. H. Tanc, K. S. Simc, V. S. Leea, M. J. Maaha, and K. W. Tan, Nickel (II) Complexes with Polyhydroxybenzaldehyde and O,N,S tridentate Thiosemicarbazone ligands: Synthesis, Cytotoxicity, Antimalarial Activity, and Molecular Docking Studies.  Journal of Molecular Structure. 2021; 1242. https://doi.org/10.1016/j.molstruc.2021.130815
21.    M. Kudrat-E-Zahan, M. S. Islam, and M. A. Bashar. Synthesis, characteristics, and antimicrobial activity of some complexes of Mn (II), Fe (III) Co(II), Ni(II), Cu(II), and Sb(III) containing bidentate Schiff base of SMDTC. Russian Journal of General Chemistry. 2015; 85(3): 667–672. https://doi.org/10.1134/S1070363215030238
22.    S. Hasnain, M. Zulfequar, and N. Nishat. Metal-containing polyurethanes from tetradentate Schiff bases: Synthesis, characterization, and biocidal activities. Journal of Coordination Chemistry. 2011; 64(6): 952–964. https://doi.org/10.1080/00958972.2011.559230
23.    M. R. Hasan, M. A. Hossain, M. A. Salam, and M. N. Uddin. Nickel complexes of Schiff bases derived from mono/diketone with anthranilic acid: Synthesis, characterization and microbial evaluation. Journal of Taibah University for Science. 2016; 10(5): 766–773. https://doi.org/10.1016/j.jtusci.2015.11.007
24.    E. M. Jouad, A. Riou, M. Allain, M. A. Khan, and G. M. Bouet. Synthesis, structural and spectral studies of 5-methyl 2-furaldehyde thiosemicarbazone and its Co, Ni, Cu, and Cd complexes.  Polyhedron. 2001; 20: 67–74.
25.    T. Paul, M. F. Hossen, M. Kudrat-E-Zahan, M. M. Haque, R. Zamir and M. A. Asraf. Structural Investigation and Antibacterial Activity of Cu (II), Co (II), Ni (II) and Zn (II) Complexes of a Schiff Base Derived from Salicylaldehyde and Thiosemicarbazide.  Asian Journal of Applied Chemistry Research. 2020; 5(3): 39-48. https://doi.org/10.9734/AJACR/2020/v5i330138
26.    M. A. Asraf, D. Sarker, M. F. Hossen, M. M. Haque, and M. Kudrat-E-Zahan. Molecular Computation and Antibacterial Activity of Cu (II) Complex of Naphthaldehyde Thiosemicarbazone. American Journal of Pure and Applied Biosciences. 2020; 85–93. https://doi.org/10.34104/ajpab.020.085093
27.    M. N. A. Bitu, M. S. Hossain, M. A. Asraf, M. F. Hossen, and M. Kudrat-E-Zahan. Synthesis, characterization and biological activity of oxovanadium (IV) complexes containing α-amino acid Schiff bases and 5,6-dimethyl-1,10-phenanthroline ligands.  Croatica Chemica Acta.  2021: 93(3). https://doi.org/10.5562/CCA3775
28.    M. Ikram, S. Rehmana, Faridoon, R. J. Baker, H. U. Rehman, A. Khand, M. I. Choudhary, and S. Rehman. Synthesis and distinct urease enzyme inhibitory activities of metal complexes of Schiff-base ligands: Kinetic and thermodynamic parameters evaluation from TG-DTA analysis. Thermochimica Acta. 2013;  555: 72–80 https://doi.org/10.1016/j.tca.2012.12.023
29.    M. S. Refat, I. M. EL-Deen, Z. M. Anwer, and S. EL-Ghol. Spectroscopic studies and biological evaluation of some transition metal complexes of Schiff-base ligands derived from 5-arylazo-salicylaldehyde and thiosemicarbazide. Journal of Coordination Chemistry. 2009; 62(10): 1709–1718.  https://doi.org/10.1080/00958970802684205
30.    J. Joseph, N. L. Mary and R. Sidambaram. Synthesis, Characterization, and Antibacterial Activity of the Schiff Bases Derived from Thiosemicarbazide, Salicylaldehyde, 5-bromosalicylaldehyde and their Copper (II) and Nickel (II) Complexes.  Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry. 2010; 40(10): 930-933. https://dx.doi.org/10.1080/15533174.2010.522661
31.    B. N. Meyer, N. A. Ferrigni, J. E. Putnam, L. B. Jacobsen, D. E. Nichols and J. L. McLaughlin. Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents.  Journal of Plant Research. 1982; 45: 31-34. https://doi.org/10.1055/s-2007-971236
32.    M. Hanif and Z. H. Chohan. Synthesis, spectral characterization and biological studies of transition metal (II) complexes with triazole Schiff bases.  Applied Organometallic Chemistry. 2013; 27: 36–44. https://doi.org/10.1002/aoc.2936
33.    R. T. Trotter, M. H. Logan, J. M. Rocha and J. L. Boneta. Ethnography and bioassay: combined methods for a preliminary screen of home remedies for potential pharmacological activity.  Journal of Ethnophamaacology. 1983; 8(1): 113-119. https://doi.org/10.1016/0378-8741(83)90092-2

Recomonded Articles:

Author(s): Suha K. Al-Mosawi, Hanan A. Al-Hazam, Abbas F. Abbas

DOI: 10.5958/0974-4150.2019.00031.2         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Tuly Paul, Faruk Hossen, Kudrat-E-Zahan, Masuqul Haque, Saddam Hossain, Rausan Zamir, Ali Asraf

DOI: 10.5958/0974-4150.2020.00052.8         Access: Open Access Read More

Author(s): Shravani S. Pawar, Sachin H. Rohane

DOI: 10.5958/0974-4150.2021.00014.6         Access: Open Access Read More

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Author(s): S.B. Junne, Archana B. Kadam, Archana Y. Vibhute, S.L. Shinde, R.B. Patil, Y.B. Vibhute

DOI:         Access: Open Access Read More

Author(s): SR Pattan, NS Dighe, SA Nirmal, AN Merekar, RB Laware, HV Shinde, DS Musmade

DOI:         Access: Open Access Read More

Author(s): K.P. Beena, G. Sathya Pooja

DOI: 10.52711/0974-4150.2022.00030         Access: Closed Access Read More

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Author(s): Sindhu. T. J, Akhilesh K. J, Anju. Jose, Binsiya K. P, Blessy Thomas, Elizabeth Wilson

DOI: 10.5958/0974-4150.2020.00026.7         Access: Open Access Read More

Author(s): Shashi Ravi Suman Rudrangi, Vijaya Kumar Bontha, Venkata Reddy Manda, Srinivas Bethi

DOI:         Access: Open Access Read More

Author(s): KP Bhusari, ND Amnerkar, PB Khedekar, MK Kale, RP Bhole

DOI:         Access: Open Access Read More

Author(s): Sapna Tyagi, Tanveer Alam, Mohd Azhar Khan, Hina Tarannum, Neha Chauhan

DOI: 10.5958/0974-4150.2018.00092.5         Access: Open Access Read More

Author(s): Kadhiravansivasamy, S. Sivajiganesan, T. Periyathambi, V. Nandhakumar, M. Pugazhenthi

DOI: 10.5958/0974-4150.2017.00016.5         Access: Open Access Read More

Author(s): Raisul Islam, Ekhlass Uddin, Ashrafuzzaman, Nur Amin Bitu, Ali Asraf, Faruk Hossen, M. Haque, Abdul Mannan, Kudrat-E-Zahan

DOI: 10.5958/0974-4150.2020.00073.5         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags