ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): P.A. Patil, R.P. Bhole, R.V. Chikhale, K.P. Bhusari, Amol Chandekar

Email(s): prashant58@gmail.com

DOI: Not Available

Address: P.A. Patil1*, R.P. Bhole1, R.V. Chikhale1, K.P. Bhusari1 and Amol Chandekar2
1Sharad Pawar College of Pharmacy, Nagpur-441 110, (MS) India
2RKDF College of Pharmacy, Bhopal (MP)
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
Six new 3,4-Dihydro-1H-pyrimidine-5-carbohydrazide Derivatives (3a-f) have been synthesized in a three step reaction. In first step 5-(Ethoxycarbonyl)-6-methyl-4-substitutedaryl-3,4-dihydropyrimidin-2(1H)-ones obtained (1a-f) and in second step 4-Substitutedaryl-6-methyl-2-pyrimidinone-5-Carbohydrazides (2a-f). Third step involves synthesis of 4-Substitutedaryl-6-methyl-2-pyrimidinone-5-(N-p-tosyl) Carbohydrazides (3a-f). Their structures are confirmed by IR, 1H- NMR, C13NMR and Mass. The compounds were tested for antihypertensive activity by non-invasive tail-cuff, and evaluated by carotid artery cannulation method for determining the diastolic blood pressure. Hypertension was induced by DOCA-salt. Anti-inflammatory activity was carried out by carrageenan induced rat-paw oedema method. Test compounds c1-8 exerted comparative anti-hypertensive activity at 10 mg/kg dose level compared to nifedipine. Compounds 3c, 3e, 3f and 2 b, 2c, 2f showed excellent results on evaluation by direct method. Test compounds 3c, 3e and 2f exerted moderate to comparative anti-inflammatory activity at the 100 mg/kg dose level compared to indomethacin. Their further investigation for analgesic activity and acute ulcerogenesis was carried out, compounds 3b, 3c and 3e showed low ulcerogenic activity. DOCA-salt hypertension; Non-invasive tail-cuff method; Carotid artery cannulation; Antihypertensive activity; Anti-inflammatory activity; Ulcerogenic activity, nifedipine, Schiff base.


Cite this article:
P.A. Patil, R.P. Bhole, R.V. Chikhale, K.P. Bhusari, Amol Chandekar. Synthesis of 3, 4-Dihydro-1H-Pyrimidine-5-Carbohydrazide Derivatives and their Pharmacological Screening. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 531-538.


Recomonded Articles:

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Author(s): Nguyen Hai Nam, Ngo Anh Ngoc

DOI:         Access: Open Access Read More

Author(s): SR Pattan, NS Dighe, SA Nirmal, AN Merekar, RB Laware, HV Shinde, DS Musmade

DOI:         Access: Open Access Read More

Author(s): Anshul Sinha, A. K. Meena, P. Panda, Bhavana Srivastava, M. D. Gupta, M. M. Padhi

DOI:         Access: Open Access Read More

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Author(s): Alok Singh Thakur, Parmanand Verma, Anish Chandy

DOI:         Access: Open Access Read More

Author(s): Sabale Prafulla, Potey Lata, Rahangdale Priya, Sabale Vidya

DOI: 10.5958/0974-4150.2019.00011.7         Access: Open Access Read More

Author(s): BS Vikram, T Srinivas Rao, K Ramesh

DOI:         Access: Open Access Read More

Author(s): A.K. Meena, M.M. Rao, Kiran Sharma, Ajay Yadav, Uttam Singh, Amit

DOI:         Access: Open Access Read More

Author(s): Nikita N. Patel, Charmy S. Kothari

DOI:         Access: Open Access Read More

Author(s): N. V. S. Venugopal, V. Nageswara Raoand, B. Sumalatha

DOI:         Access: Open Access Read More

Author(s): Shashi Ravi Suman Rudrangi, Vijaya Kumar Bontha, Venkata Reddy Manda, Srinivas Bethi

DOI:         Access: Open Access Read More

Author(s): Merlin NJ, Parthasarathy V, Manavalan R, Devi P, Meera R

DOI:         Access: Open Access Read More

Author(s): Jacob Jincy, Dey Tathagata, Ghate Manjunath, Baby Shaji

DOI:         Access: Open Access Read More

Author(s): P.A. Patil, R.P. Bhole, R.V. Chikhale, K.P. Bhusari, Amol Chandekar

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags