ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sejal P. Gandhi, Mohit G. Dewani, Tejas C. Borole, Mrinalini C. Damle

Email(s): mcdamle@rediffmail.com

DOI: Not Available

Address: Sejal P. Gandhi, Mohit G. Dewani, Tejas C. Borole and Mrinalini C. Damle*
Department of Pharmaceutical Chemistry, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune – 411001, Maharashtra, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2011


ABSTRACT:
Trandolapril is a drug in current clinical practice as antihypertensive. It modulates the renin-angiotensin-aldosterone system that plays a major part in regulating blood pressure. The present study describes degradation of Trandolapril under different ICH prescribed stress conditions (hydrolysis, oxidation, dry heat, wet heat and photolysis) and establishment of a stability-indicating HPTLC assay method. Though a separate peak for the products of degradation was not obtained, the peak purity of the drug was observed. For HPTLC Silica Gel 60 F254 plate and mobile phase consisting of ethyl methyl ketone : acetic acid (8 : 0.25) was used to achieve separation and quantitation was done at 220 nm. The method was found to be simple, specific, precise, and stability indicating.


Cite this article:
Sejal P. Gandhi, Mohit G. Dewani, Tejas C. Borole, Mrinalini C. Damle. Development and Validation of Stability Indicating HPTLC Method for Determination of Trandolapril as Bulk Drug. Asian J. Research Chem. 4(3): March 2011; Page 437-440.


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