ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Pandeya S.N, Ranjana, Neha Rajput

Email(s): nr.17neha@gmail.com

DOI: Not Available

Address: Pandeya S.N, Ranjana and Neha Rajput*
1Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow-226002 (U.P.), India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2011


ABSTRACT:
Fluoroquinolones are known as a major class of antibacterial agents and widely used to treat patients with infections. Derivatives of ciprofloxacin were synthesized with phenyl hydrazine, hydrazine hydrate, and several acyclic secondary amines and evaluated for antibacterial activity in-vitro against gram positive and gram negative bacteria. Among the synthesized compounds 1.1(A), 1.2(B), 2(C), 2.1.(a),2.1.(b), 2.2(a), 2.2(b), 2.3(a), 2.3(b), were found to be water soluble and the most active compounds with a MIC of 0.5 and 1.5 µg/ml against S.aureus, S. typhimurium , E. coli. These compounds were found to be more active than ciprofloxacin.


Cite this article:
Pandeya S.N, Ranjana, Neha Rajput. Molecular Modification in Fluoroquinolones. Asian J. Research Chem. 4(4): April, 2011; Page 650-654.


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