ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rege P.V., Sathe P.A., Salvi V.S.

Email(s): pvr_2008@yahoo.co.in / pralhad1806@gmail.com

DOI: Not Available

Address: Rege P.V.1*, Sathe P.A. 1 and Salvi V.S.2
Department of Chemistry, Ramnarain Ruia College, Matunga (E), Mumbai-400019.
*Corresponding Author

Published In:   Volume - 4,      Issue - 5,     Year - 2011


ABSTRACT:
Two simple, sensitive, accurate, precise, rapid and economical methods were developed for the estimation of Norfloxacin and Tinidazole from combined tablet dosage form. First method is based simultaneous equations and second method is based on Q-analysis (absorbance ratio method). Norfloxacin and Tinidazole show absorbance maxima at 277nm and 308nm in 0.1N Methanolic-HCI (30:70), respectively. The linearity was obtained in the concentration ranges of 4-14 µg/ml for Norfloxacin and 6-24 µg/ml for Tinidazole. In the first method concentration and subsequently amount of drug determined by using simultaneous equations and in second method concentration and amount of drugs determined by using ratio of absorbance at iso-absorptive point and at ?max of one of the drug. The results of analysis have been validated statistically and by assay and recovery studies.


Cite this article:
Rege P.V., Sathe P.A., Salvi V.S.. Simultaneous Spectrophotometric Estimation of Norfloxacin and Tinidazole from Combined Tablet Dosage Form. Asian J. Research Chem. 4(5): May, 2011; Page 729-733.

Cite(Electronic):
Rege P.V., Sathe P.A., Salvi V.S.. Simultaneous Spectrophotometric Estimation of Norfloxacin and Tinidazole from Combined Tablet Dosage Form. Asian J. Research Chem. 4(5): May, 2011; Page 729-733.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2011-4-5-13


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