ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Hemant Badwaik, S. Venkataraman, Deepa Thakur, Minu Vinod, J.Raamamurthy, Kiran Deshmukh

Email(s): hemantbadwaik@rediffmail.com

DOI: Not Available

Address: Hemant Badwaik1*, S. Venkataraman2, Deepa Thakur1, Minu Vinod1, J.Raamamurthy2 and Kiran Deshmukh2.
1Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G)
2K.M. College of Pharmacy, Madurai (T.N)
*Corresponding Author

Published In:   Volume - 4,      Issue - 6,     Year - 2011


ABSTRACT:
Acetanilide was cyclized via Vilsmeier–Haack reagent to give 2- chloro -3- formyl quinoline. The aldehydic group was protected to prevent the preferential attack of nitrogen nucleophiles. The protection of aldehydic group in the present system was achieved with ethylene glycol to afford dioxolan derivative. Dioxolan derivative treated with nitro substituted phenyl hydrazine in alcoholic solution followed by deprotection of aldehydic group afforded the 2-(2-(2-nitrophenyl) hydrazinyl) quinoline-3-carbaldehyde and 2-(2-(2, 4-dinitrophenyl) hydrazinyl) quinoline-3-carbaldehyde. The synthesized derivatives were screened for antimicrobial activity.


Cite this article:
Hemant Badwaik, S. Venkataraman, Deepa Thakur, Minu Vinod, J.Raamamurthy, Kiran Deshmukh. Antibacterial Evaluation of Novel 2-Aryl-Quinoline -3- Carbaldehyde Derivatives. Asian J. Research Chem. 4(6): June, 2011; Page 893-895.


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