Neena Rajan, Baskar L., C.I. Sajeeth, Y. Haribabu, G. Unnikrishnan
Neena Rajan*, Baskar L., C.I. Sajeeth, Y. Haribabu, G. Unnikrishnan
Department of Pharmaceutical Chemistry, Grace College of Pharmacy,
Kodunthirappully P.O, Palakkad, 678004, Kerala, India, Fax: 0491-2509393
Volume - 7,
Issue - 3,
Year - 2014
A few substituted naphthoquinone derivatives (BA1-BA5) were synthesized and characterized on the basis of FT-IR, 1H NMR and DART-MS spectra. Formation of all naphthoquinone derivatives (BA1-BA5) have been confirmed by their respective colour, and other physiochemical parameters and by the difference in the melting point from that of the reactant and disappearance of reactant spot in thin layer chromatography (TLC; Silica gel-G plate; Toluene: Ethyl acetate: Methanol). The melting points of all the final compounds were compared with the previous reported results and are uncorrected. The challenge of synthesizing lawsone (2-hydroxy-1, 4-naphthoquinone) derivatives to improve their therapeutic efficacy. The search for novel scaffold in antimicrobial agents is an important line in this review because of the resistance acquired by several pathogenic microorganisms.
The synthesized compounds (BA1-BA5) were screened for their in-vitro growth inhibiting activity against different strains of bacteria viz., Bacillus subtilis (ATCC-6633) and Escherichea coli (NCIM-2118) at the concentrations of 10 and 50 µg/ml using disc diffusion technique. The standard drug, Gentamycin was used in this study. The zone of inhibition was measured as a parameter for this assay. Results from the zone of inhibition of the test compounds (BA1-BA5) have been recorded in Table-3. It is quite evident from the results that the compounds (BA1-BA5) are significantly active against both gram positive and gram negative bacterial strains used in this microbiological assay when compared with that of standard drug.
Cite this article:
Neena Rajan, Baskar L., C.I. Sajeeth, Y. Haribabu, G. Unnikrishnan. Biologically Active Lawsones: Synthesis, Characterization and Antimicrobial Activity of Some Naphthoquinone Derivatives. Asian J. Research Chem. 7(3): March 2014; Page 281-284.