Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Physiochemical Investigation and Role of Indicator Parameter in the Modeling of Tetrahydroimidazole Benzodiazepine -1- one (TIBO): A QSAR Study

Author(s): Lokendra Kumar Ojha, Ajay M Chaturvedi, Arpan Bhardwaj, Abhilash Thakur, Mamta Thakur

Email(s): ojha_lokendra@rediffmail.com

DOI: Not Available

Address: Lokendra Kumar Ojha*, Ajay M Chaturvedi*, Arpan Bhardwaj*, Abhilash Thakur1, Mamta Thakur2
*Department of Chemistry, Govt. Madhav Science PG College, Ujjain (MP), INDIA
Department of Applied Science, NITTTR, Bhopal (MP), INDIA
Department of Pharma. Chemistry, Softvision College, Indore (MP), INDIA
*Corresponding Author

Published In:   Volume - 5,      Issue - 3,     Year - 2012

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ABSTRACT:
The aim of the author in this paper is to emphasize the role of indicator parameter for TIBO 89 derivatives with the help of computational drug design. A QSAR study has been carried out to know the drug receptor binding affinity of the TIBO derivatives. In this regard multiple linear regression analysis (MLR) method has been used and different indicator parameter is used to obtain the better mathematical model in the particular set. The substitution at the –Z position on five member ring, –R position on seven member ring and –X position on benzene ring plays vital role in this concern. The statistical analysis multiple R= .9170, standard error of estimation (Se= .5572) and Fisher Ratio (F= 122.383) values gives the satisfactory explanation of the data set to know the effect of indicator parameter on the biological activity.


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Cite this article:
Lokendra Kumar Ojha, Ajay M Chaturvedi, Arpan Bhardwaj, Abhilash Thakur, Mamta Thakur. Physiochemical Investigation and Role of Indicator Parameter in the Modeling of Tetrahydroimidazole Benzodiazepine -1- one (TIBO): A QSAR Study. Asian J. Research Chem. 5(3): March 2012; Page 377-382.


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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