ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Bhavin Vaishnani, Ritu Kimbahune, Prachi Kabra, Sanjay Surani, L.V.G. Nargund

Email(s): prachi.v.kabra@gmail.com

DOI: Not Available

Address: Bhavin Vaishnani, Ritu Kimbahune, Prachi Kabra*, Sanjay Surani, L.V.G. Nargund
Department of Quality Assurance, Nargund College of Pharmacy, Dattatreyanagar, II Main,100 Ft Ring Road, BSK III Stage, Bangalore- 560 085, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 4,     Year - 2012


ABSTRACT:
In the present study, a reverse phase high performance liquid chromatographic method was developed and validated for the determination of Rasagiline in tablet dosage form with the use of Caffeine as an internal standard. Chromatographic separation was carried out on a RP-18 column using a mobile phase consisting of acetonitrile: isopropyl alcohol: water (10:20:70, v/v/v) adjusted at pH 2.5 with o-phosphoric acid (1%). The flow rate was maintained at 0.8 ml min-1 and UV detection was measured at 210 nm. The calibration curve was linear over the range 1-200µgml-1. R.S.D. for precision was <3%. The results of accuracy study was observed in the range of 95.16% to 102.24 % with R.S.D. < 3%. LOD and LOQ were found to be 0.4044µgml-1 and 1.2133µgml-1, respectively. The method was simple, rapid, and easy to apply, making it suitable for routine analysis of Rasagiline in tablet dosage form.


Cite this article:
Bhavin Vaishnani, Ritu Kimbahune, Prachi Kabra, Sanjay Surani, L.V.G. Nargund. Validated RP-HPLC Method for Estimation of Rasagiline in Tablet Dosage Form. Asian J. Research Chem. 5(4): April 2012; Page 515-519.


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