An Iodine catalyzed (3, 5)-thionium-ene-type cyclization for the facile construction of various multisustituted tetrahydrothiopyrans was successfully developed from aldehyde (aromatic and aliphatic) and 6-methylhept-5-en-2thiol, 6-methyl-2-phenyl hept-5-en-2-thiol and 2, 6-dimethylhept-5-en-2-thiol in the presence of iodine under mild and neutral conditions. This method is simple, convenient and cost-effective.
Cite this article:
N. Prudhvi Raju, K. Murali Krishna, B. Jagan Mohan Reddy. A typical (3, 5)-thionium-ene-cyclization through Molecular Iodine Catalyzed Convergent Assembly of Tetrahydrothiopyrans. Asian J. Research Chem. 6(10): October 2013; Page 906-910.